DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and par-1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	161/438 - (36%)
Similarity:	233/438 - (53%)	Gaps:	63/438 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SANGQPLVK---------------IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIK 65
            ||.|.|.::               ||.|.|..|:|.|.|.|||:.:|..|..:||:||:::.::.
  Fly   226 SAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLN 290

  Fly    66 --SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQA 128
              ||.   |:.||::.:|:..||:|:||:|||.|...:::||||.||||:|||:|.||:::|.:|
  Fly   291 PGSLQ---KLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEA 352

  Fly   129 RRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAA 193
            |..|:||:|.|.|||:..|:|||||.||||||..:::||||||.||....|..|.|.||||.|||
  Fly   353 RVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAA 417

  Fly   194 PEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVC 258
            ||:..||.|.|||||:||.|||||.|:.|:||||...:..|..::..|.:.||.|::....||:.
  Fly   418 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLR 482

  Fly   259 QMLQVDPLKRANIEEIKKHEW----FQKD-LPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETE 318
            :.|.::|.|||::|.|...:|    |::| |..|:.|.:...|...|      |.....|...:|
  Fly   483 KFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRI------EALVAMGYNRSE 541

  Fly   319 VHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAP 383
            :..| ||...:|.:...|.|:  .::..|                       |....|.......
  Fly   542 IEAS-LSQVRYDDVFATYLLL--GRKSTD-----------------------PESDGSRSGSSLS 580

  Fly   384 LATVTVGGGTSASSGTATPVPPVAGG-----TPSSTIPIRPHPERIAP 426
            |..:: |....|::|:|:...|...|     :.|||.|.|.....:.|
  Fly   581 LRNIS-GNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	125/260 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/62 (18%)
		AMPKA_C	457..580	CDD:213378
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	122/254 (48%)
		S_TKc	253..504	CDD:214567	122/253 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	11/46 (24%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910