Protein Alignment AMPKalpha and Smok2a

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_038769.1
• Gene: Smok2a / 27263
• MGIID: 1351487
• Length: 504
• Species: Mus musculus
• Alignment Length: 488
• Identity: 130/488 - (26%)
• Similarity: 226/488 - (46%)
• Gaps: 63/488 - (12%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |.:..|:|.|...|||:..|::|...||||::.:::.....::.    |.:.|.:..||:||.|.
Mouse    28 YEMLGTIGHGGSTKVKLARHRLTGTHVAVKMIPKREYWCKPLMS----EAELLMMADHPNIISLL 88

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            |||.|...:::|||...|..|:.:|...|.|||.:||..|:|::|.::|||...||||||||:|:
Mouse    89 QVIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAINYCHNQGIVHRDLKPDNI 153

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            :::.:..|||.||||...:..|:.|...||:..::||||:..:.|.||::|:|:.||:||.::.|
Mouse   154 MVEKDGRVKIIDFGLGIQVKPGQKLNLFCGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVTG 218

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAY 287
            .:|||...:..|.::|.:|.:.:|..|:.::.:|:..::..:|..|..:.|:..|.|..|.  :.
Mouse   219 KIPFDAASIEKLRKQIVAGKYSVPCRLSVKLHHLITLLMTDNPELRPTVAEVMMHPWVTKG--SG 281

  Fly   288 LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQ 352
            :||...|:...:....|:.:.....|.:..::.:||.....::.:| :|.|:  .|:...:....
Mouse   282 VFPDPCEEQIPLKPDPAIVKAMGHIGFQAQDIEDSLRQRKFNETMA-SYCLL--KKQILKECDRP 343

  Fly   353 INEINNFFVAGSPPPPPPPPVPQ------------------SSMDHQAPLATVTVGGGTSASSGT 399
            |.        ..|..|...|.|.                  :|:...|.......|..||.....
Mouse   344 IR--------AQPMNPSVTPFPSLVDTPTFHLGLRRRETEPTSLRLSANRQMSVCGRSTSKKRDR 400

  Fly   400 ATPVPPVAGGTPSSTIPIRPHPE------RIAPMRDRQLAMSVQTSGGGAFPEKTARGGT----- 453
            :...|    |..|..|.|.|..:      |..|..:....:....|.     :::..|.|
Mouse   401 SFSWP----GVLSRPINITPTMDQTHTCTRSVPCINSNFCIIHPNSS-----DESTEGHTSASAE 456

  Fly   454 --PIKRAKWHLGIRSQSKPNDIMLEVYRAMKAL 484
              |::...|..||:..:.      ::..||:.|
Mouse   457 DKPVRSRGWPRGIKGWTS------KIGNAMRKL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	89/251 (35%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/62 (15%)
		AMPKA_C	457..580	CDD:213378	6/28 (21%)
Smok2a	NP_038769.1	STKc_AMPK-like	27..275	CDD:270905	89/250 (36%)
		S_TKc	28..276	CDD:214567	89/251 (35%)
		UBA_MARK_Par1	295..334	CDD:270522	7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..403		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..469		4/30 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010