Protein Alignment AMPKalpha and Hunk

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_056570.1
• Gene: Hunk / 26559
• MGIID: 1347352
• Length: 714
• Species: Mus musculus
• Alignment Length: 628
• Identity: 175/628 - (27%)
• Similarity: 297/628 - (47%)
• Gaps: 120/628 - (19%)

  Fly    24 KIGHYLLGA-TLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK-IRREIQNLKLFRHP 86
            ::|:||:|: .||.|:|.||:.|.|.:|..|||:|::::::.|....|.| :|||.|..::.|||
Mouse    57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHP 121

  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            :|.:|..::.|.:..:::||...||.|...|.:..:|.|.:|||:.:|:||.|::.||..:||||
Mouse   122 NITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRD 186

  Fly   152 LKPENLLLDHNMHVKIADFGLSN---MMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCG 213
            ||.||||||.:.::|:.||||||   ::...:...|.||||.|||||:::.|.| ||::|:||.|
Mouse   187 LKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIG 250

  Fly   214 VILYALLCGTLPFDDE--HVPTLFRK-IKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIK 275
            |.:||:|.|||||..|  .:..|::| :...:.|:|..|:...||.:..:|:.||:||.||::..
Mouse   251 VNMYAMLTGTLPFTVEPFSLRALYQKMVDKAMNPLPTQLSTGAVNFLRSLLEPDPVKRPNIQQAL 315

  Fly   276 KHEWFQKD----LPAYL-FPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
            .:.|..::    :|..: :|:.|..:.  :....|..:..|.|.|.::|.|::||......|||
Mouse   316 ANRWLNENYTGKVPCNVTYPNRISLED--LSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAI- 377

  Fly   336 YHLI-------IDNKRFADDA---ANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVG 390
            |.|:       :..|....|:   ..|:.:|........|              ::|.|.|.|..
Mouse   378 YFLLNKKLERYLSGKSDIQDSICYKTQLYQIEKCRATKEP--------------YEASLDTWTRD 428

  Fly   391 GGTSASSGTATPVPPVAG-------------GTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGG 442
            ....|............|             ..||..   :|.|..|..::..:..:..:.:...
Mouse   429 FEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHK---QPSPSLITQLQSTKALLKDRKASKS 490

  Fly   443 AFPEKTA-----------------------------RGGTPIKRAKWHL-GIRSQS---KPNDIM 474
            .||:|.:                             |....:|:.:.|. |..|.|   |...::
Mouse   491 GFPDKDSFVCRNLFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKLEPHQPGPGSASILPKEEPLL 555

  Fly   475 LEVYRAMKALSYE--WKIINP-YHVRV--------RR--------QNVKTGKFSKMSLQLYQVDA 520
            |::.|:.:::..|  .::::| :|.|:        ||        |.:.:|..|.:...|:
Mouse   556 LDMVRSFESVDREDHIELLSPSHHYRILSSPVSLARRNSSERTLSQGLLSGSTSPLQTPLH---- 616

  Fly   521 KSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTG 563
             |.|:.|.....:...:.:.|    .:|||:..:|:  |||.|
Mouse   617 -STLVSFAHEEKNSPPKEEGV----CSPPPVPSNGL--LQPLG 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	108/262 (41%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	17/72 (24%)
		AMPKA_C	457..580	CDD:213378	29/130 (22%)
Hunk	NP_056570.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		STKc_HUNK	58..320	CDD:270972	108/262 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..658		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..714