DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and cdr1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_593874.1	Gene:	cdr1 / 2543666	PomBaseID:	SPAC644.06c	Length:	593	Species:	Schizosaccharomyces pombe

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	218/543 - (40%)	Gaps:	154/543 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            ||.:.||.|||||:...|::.:|..|....|:||:..:       ...|..||..::|.|||:|:
pombe     9 IGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIR-------YASIGMEILMMRLLRHPNIL 66

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            :||.|.:....:::.:|||..||||.||.|||.|.|.:|..:..||:..|.:|||....|||||.
pombe    67 RLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKL 131

  Fly   155 ENLLLDHN-MHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYA 218
            ||:|:..| ..:||||||::.:..:...|...|||.:|.|||::|.|.|.|...|:||||||||:
pombe   132 ENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYS 196

  Fly   219 LLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF--- 280
            ||...|||..::...::.||:.|.:.:|..::....:|:.:||.|:|..|..|.|:..|.:.
pombe   197 LLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGC 261

  Fly   281 ----QKDLPAYLFPS-SIEQ-DSNVIDTYAV---------------------------------- 305
                ..|......|| ||:: |..|:|...|
pombe   262 TSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKVLSEILR 326

  Fly   306 -----------------------------AEVCTKFGVKETEVHNSLLSGDPHDQLA-------- 333
                                         |.:.|...||.....||..|.:..|:||
pombe   327 DDMLKKQRFDENKYLSLYDLIHDNNLFTKASISTTSLVKSNVSTNSRKSSNFEDELARRVSSPLS 391

  Fly   334 ----------------------IAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPP---- 372
                                  .|.|.::.|....||      :.|..||.      ||..
pombe   392 ALNQMSQSPIPIRVSSDKDYDSYACHEVVSNPSTLDD------DYNYMFVC------PPEEYTYS 444

  Fly   373 ---VPQSSMDHQA-PLAT--------------VTVGGGTSASSGTATPVPPVAGG--TPSSTIPI 417
               |...|:|.|: |..|              |.:...|:.||        .|.|  ||.|....
pombe   445 TDNVRTDSLDLQSLPTPTLEQLESVPFNRYGYVRIFPSTTLSS--------TASGYYTPDSLSTP 501

  Fly   418 RPHPERIAPMRDRQLAMSVQTSG 440
            .|..:.:..:.|.|:...||.||
pombe   502 EPSIDGLTNLDDVQVGGFVQGSG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	101/255 (40%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	19/155 (12%)
		AMPKA_C	457..580	CDD:213378
cdr1	NP_593874.1	STKc_BRSK1_2	10..258	CDD:270983	100/254 (39%)
cdr1	NP_593874.1	Pkinase	12..258	CDD:278497	99/252 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910