Protein Alignment AMPKalpha and ppk9

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_593404.1
• Gene: ppk9 / 2541773
• PomBaseID: SPAC23H4.02
• Length: 532
• Species: Schizosaccharomyces pombe
• Alignment Length: 583
• Identity: 169/583 - (28%)
• Similarity: 276/583 - (47%)
• Gaps: 96/583 - (16%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.:|||.|||.|...|||:|:|..|..|||:|::...:::..|...:::||:..|:...||:||
pombe    20 VGPWLLGRTLGQGNLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWKRLQREVTILRQLHHPNII 84

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            .||||...|....:.:||:. .:|...:|||.:|.|...|:.|:||:..:||||.|.:.|||||.
pombe    85 TLYQVFRVPKYTVLALEYMD-TDLHSMVVKHNRLDECTTRKIFRQIVHAIDYCHLHRVAHRDLKL 148

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||:||:.::.||:.||||||.||||.||.||||:|:|||||||.|:.|.|.:||:|.||::||.:
pombe   149 ENILLNKDLVVKLTDFGLSNFMLDGSFLSTSCGTPHYAAPEVIQGRYYDGCDVDVWGCGILLYLM 213

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDL 284
            |.|..||:|..:..:..::..||:.||.:::....:|:.|||.|.|..|..:.||.:|.||..||
pombe   214 LVGEFPFEDVTISNVLSRVCKGIYTIPSFVSSSASDLIRQMLMVLPTSRIKVAEIMQHPWFIADL 278

  Fly   285 PAY-LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
            |.: ..||.                .:.|..|    |.|:....|  .|||.:...|.:   ...
pombe   279 PTHSRLPSR----------------TSSFSSK----HRSVTFSPP--DLAILFDPSITS---PSS 318

  Fly   349 AANQINEINNFFVAGSPPP--------PPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATP--V 403
            :..||.:..:........|        |.|.|.......::...:..:.....:.|||...|  :
pombe   319 SVGQIPQPTDHSALSPSKPMSISGTESPNPDPASLCYSSYEDLYSATSWHSDMAESSGFLDPTDI 383

  Fly   404 PPVAGGTPSSTIPIRPH-PERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTP--IKRAKWHLGIR 465
            ||:    ||:...:|.. |:|.|...::            .:....:|...|  ::..:||.||:
pombe   384 PPI----PSNVETLRSSLPQRHASFMNK------------VYNHPLSRPPAPNRLRSLRWHYGIQ 432

  Fly   466 SQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMS------------LQLYQV 518
            :...|.:::.::..|:..|...::..:      ....:|..|:...|            ::|:.:
pombe   433 TAKNPIEVLRKLCEALLELGARFRPCD------EESFLKENKYKVFSCITCHNSPVYLVIELFSI 491

  Fly   519 DAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLA 581
            ...:.::|.:..::|:                 |:.......|     |.|.|:...||:::|
pombe   492 GPSASVIDIRFSSSDD-----------------SIKYTSSYSP-----MPFLEVVKQLILKIA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	112/254 (44%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/62 (18%)
		AMPKA_C	457..580	CDD:213378	20/134 (15%)
ppk9	NP_593404.1	STKc_AMPK-like	22..273	CDD:270905	111/251 (44%)
		AMPKA_C_like	426..531	CDD:473060	20/132 (15%)