DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and ppk9

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_593404.1	Gene:	ppk9 / 2541773	PomBaseID:	SPAC23H4.02	Length:	532	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	169/583 - (28%)
Similarity:	276/583 - (47%)	Gaps:	96/583 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.:|||.|||.|...|||:|:|..|..|||:|::...:::..|...:::||:..|:...||:||
pombe    20 VGPWLLGRTLGQGNLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWKRLQREVTILRQLHHPNII 84

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            .||||...|....:.:||:. .:|...:|||.:|.|...|:.|:||:..:||||.|.:.|||||.
pombe    85 TLYQVFRVPKYTVLALEYMD-TDLHSMVVKHNRLDECTTRKIFRQIVHAIDYCHLHRVAHRDLKL 148

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||:||:.::.||:.||||||.||||.||.||||:|:|||||||.|:.|.|.:||:|.||::||.:
pombe   149 ENILLNKDLVVKLTDFGLSNFMLDGSFLSTSCGTPHYAAPEVIQGRYYDGCDVDVWGCGILLYLM 213

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDL 284
            |.|..||:|..:..:..::..||:.||.:::....:|:.|||.|.|..|..:.||.:|.||..||
pombe   214 LVGEFPFEDVTISNVLSRVCKGIYTIPSFVSSSASDLIRQMLMVLPTSRIKVAEIMQHPWFIADL 278

  Fly   285 PAY-LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
            |.: ..||.                .:.|..|    |.|:....|  .|||.:...|.:   ...
pombe   279 PTHSRLPSR----------------TSSFSSK----HRSVTFSPP--DLAILFDPSITS---PSS 318

  Fly   349 AANQINEINNFFVAGSPPP--------PPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATP--V 403
            :..||.:..:........|        |.|.|.......::...:..:.....:.|||...|  :
pombe   319 SVGQIPQPTDHSALSPSKPMSISGTESPNPDPASLCYSSYEDLYSATSWHSDMAESSGFLDPTDI 383

  Fly   404 PPVAGGTPSSTIPIRPH-PERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTP--IKRAKWHLGIR 465
            ||:    ||:...:|.. |:|.|...::            .:....:|...|  ::..:||.||:
pombe   384 PPI----PSNVETLRSSLPQRHASFMNK------------VYNHPLSRPPAPNRLRSLRWHYGIQ 432

  Fly   466 SQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMS------------LQLYQV 518
            :...|.:::.::..|:..|...::..:      ....:|..|:...|            ::|:.:
pombe   433 TAKNPIEVLRKLCEALLELGARFRPCD------EESFLKENKYKVFSCITCHNSPVYLVIELFSI 491

  Fly   519 DAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLA 581
            ...:.::|.:..::|:                 |:.......|     |.|.|:...||:::|
pombe   492 GPSASVIDIRFSSSDD-----------------SIKYTSSYSP-----MPFLEVVKQLILKIA 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	112/254 (44%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/62 (18%)
		AMPKA_C	457..580	CDD:213378	20/134 (15%)
ppk9	NP_593404.1	STKc_AMPK-like	22..273	CDD:270905	111/251 (44%)
		S_TKc	23..274	CDD:214567	111/251 (44%)
		AMPKA_C_like	426..531	CDD:302605	20/132 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010