Protein Alignment AMPKalpha and Gm4922

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_808374.1
• Gene: Gm4922 / 237300
• MGIID: 3644318
• Length: 497
• Species: Mus musculus
• Alignment Length: 459
• Identity: 130/459 - (28%)
• Similarity: 208/459 - (45%)
• Gaps: 44/459 - (9%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |.:..||......:|::..|.:|.|.||||.|..|:.....|     .|::.:|:..||:|:.|.
Mouse    28 YTVLKTLSQHGTTEVRLCSHHLTGVTVAVKALKYQRWWEPKV-----SEVEIMKMLSHPNIVSLL 87

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            |||.|..:|::|||...|.:|.:.:.:...|:|.:||..|.|::|.:.|||...:|||||||:|:
Mouse    88 QVIETEQNIYLIMEVAQGTQLHNRVQEARCLKEDEARSIFVQLLSAIGYCHGEGVVHRDLKPDNV 152

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            ::|.:.:|||.||||....:.|:.|...||:..:..||:..|..|.||:||||:.||:||.::.|
Mouse   153 IVDEHGNVKIVDFGLGARFMPGQKLERLCGAFQFIPPEIFLGLPYDGPKVDIWALGVLLYYMVTG 217

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAY 287
            ..||....:..:.:::..|.:.||..|:|.:.:::..:|..:..:|...:::..|.|.|:.....
Mouse   218 IFPFVGSTLSEISKEVLQGRYEIPYNLSKDLRSMIGLLLATNARQRPTAQDLLSHPWLQEGEKTI 282

  Fly   288 LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPH---DQLAIAYHLIIDNKRFADDA 349
            .|.|:  .|::..|...:|.: ...|....::..||    .|   |:....|:|:  ......|.
Mouse   283 TFHSN--GDTSFPDPDIMAAM-KNIGFHVQDIRESL----KHRKFDETMATYNLL--RAEACQDD 338

  Fly   350 ANQINEINNFFVAGSPPPPPP--------PPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPV 406
            .|.:.  ......|.||.|..        ||..::|......|.:.|.......:.||..|.||.
Mouse   339 GNYVQ--TKLMNPGMPPFPSVTDSGAFSLPPRRRASEPSFKVLVSSTEEHQLRQTGGTNAPFPPK 401

  Fly   407 AGGTPSSTIPIRPHPERIAP-----------MRDRQLAMSVQTSGGGAFPEK----TARGGTPIK 456
            .  ||:.....:......||           ..|.....|.|.....:.|||    |:...||..
Mouse   402 K--TPTMGRSQKQKRAMTAPCICLLRNTYIDTEDSSFCTSSQAEKTSSDPEKSETSTSCPLTPRG 464

  Fly   457 RAKW 460
            ..||
Mouse   465 WRKW 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	85/251 (34%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	11/65 (17%)
		AMPKA_C	457..580	CDD:213378	2/4 (50%)
Gm4922	NP_808374.1	STKc_AMPK-like	27..274	CDD:270905	85/250 (34%)
		UBA_MARK_Par1	293..330	CDD:270522	8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..460		6/20 (30%)