Protein Alignment AMPKalpha and Smok2b

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001161385.1
• Gene: Smok2b / 236574
• MGIID: 3037705
• Length: 484
• Species: Mus musculus
• Alignment Length: 473
• Identity: 128/473 - (27%)
• Similarity: 220/473 - (46%)
• Gaps: 57/473 - (12%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92
            |::..|:|.|...||.:..|::|...||||::.    ||......:..|::.|.:..||:||.|.
Mouse     8 YVMLETIGHGGCSKVMLARHRLTGSHVAVKMIR----KSECWCNPVMSEVELLMMADHPNIISLL 68

  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157
            |||.|...:::|||...|..|:.:|...|.|||.:||..|:|::|.::|||...||||||||:|:
Mouse    69 QVIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAMNYCHNQGIVHRDLKPDNI 133

  Fly   158 LLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCG 222
            :::.:..|||.||||...:..|:.|...||:..::||||:..:.|.||::|:|:.||:||.::.|
Mouse   134 MVEKDGKVKIIDFGLGTQVKPGQKLNLFCGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVTG 198

  Fly   223 TLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAY 287
            .:|||...:..|.|:|.:|.:.:|..|:.::.:|:..::..:|..|..:.|:..|.|..:.  :.
Mouse   199 KVPFDAASIQKLVRQILAGKYFVPSRLSVELRDLISLLMTANPKLRPTVAEVMVHPWVTEG--SG 261

  Fly   288 LFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQ 352
            :||...|:...:....|:.:.....|.:..::.:||.....::.:| :|.|:  .|:...:....
Mouse   262 VFPDPCEEQMPLKPNPAIVKAMGYIGFQAQDIEDSLRQRKFNETMA-SYCLL--KKQILKECDRP 323

  Fly   353 INEINNFFVAGSPPPPPPPPVPQ------------------SSMDHQAPLATVTVGGGTSASSGT 399
            |.        ..|..|...|.|.                  :|:...|.......|..||.....
Mouse   324 IR--------AQPMNPSVTPFPSLVDTSTFHLGLRRRETEPTSLRLSANRQMSVCGRSTSKKRDR 380

  Fly   400 ATPVPPVAGGTPSSTIPIRPHPERIAPMRDR------QLAMSVQTSGGGAFPEKTARGGT----- 453
            ....|.|: |.|..|.....|..    .|.|      .:..::|.:..    :.:..|.|
Mouse   381 RFSWPSVS-GRPLHTTHTMDHTH----TRTRSVPCIYSMFCTIQPNSS----DDSTEGHTSASAE 436

  Fly   454 --PIKRAKWHLGIRSQSK 469
              |::...|..||:..::
Mouse   437 DKPVRSRGWPRGIKGWTR 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	91/251 (36%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/62 (15%)
		AMPKA_C	457..580	CDD:213378	3/13 (23%)
Smok2b	NP_001161385.1	STKc_AMPK-like	7..255	CDD:270905	91/250 (36%)
		UBA_MARK_Par1	275..314	CDD:270522	7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..400		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..450		5/31 (16%)