DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AMPKalpha and Sik2

DIOPT Version :9

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_848825.2 Gene:Sik2 / 235344 MGIID:2445031 Length:931 Species:Mus musculus


Alignment Length:440 Identity:162/440 - (36%)
Similarity:243/440 - (55%) Gaps:63/440 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            |::|.|.:..|||.|.|..||:|.|:||:.:||:||:::.::.::: :.||.||:|.:|:..|||
Mouse    15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN-LEKIYREVQIMKMLDHPH 78

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||:.|.|.::::.||...||:|||:..||:|.|.:|||.|.||:|.|||||...:|||||
Mouse    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDL 143

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            |.||||||:||::||||||..|....||.|.|.||||.||||||..|:.|.||::||||.||:||
Mouse   144 KAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            .|:||.||||...:|.|.:::..|.|.||.::::...:|:.:||.:||.||.:|.:||:|:|...
Mouse   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLI 273

  Fly   283 DLPA---YLFPSSIEQDSNVID-TYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNK 343
            ::|.   .|:|...|.:.::.: ...|..:....|:.:.:...| |....::..|..|.|:::..
Mouse   274 EVPVQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVES-LQNKSYNHFAAIYFLLVERL 337

  Fly   344 RFADDAANQINEINNFFVAGSPPPPPPPPVPQ---------SSMDHQAPLATVTVGGGTSASSGT 399
            :         :..::|            ||.|         |::..|......|||         
Mouse   338 K---------SHRSSF------------PVEQRLDGRQRRPSTIAEQTVAKAQTVG--------- 372

  Fly   400 ATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTA 449
                           :|:..||..:..||...|.   |.|...||...|:
Mouse   373 ---------------LPVTLHPPNVRLMRSTLLP---QASNVEAFSFPTS 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 129/254 (51%)
UBA_AID_AMPKalpha 297..360 CDD:270521 7/63 (11%)
AMPKA_C 457..580 CDD:213378
Sik2NP_848825.2 STKc_SIK 19..271 CDD:270973 128/252 (51%)
S_TKc 20..271 CDD:214567 128/251 (51%)
UBA_SIK2 297..341 CDD:270592 7/53 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..586
RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269|PubMed:29211348 595..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..662
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..842
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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