DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and Sik2

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_848825.2 Gene:Sik2 / 235344 MGIID:2445031 Length:931 Species:Mus musculus


Alignment Length:440 Identity:162/440 - (36%)
Similarity:243/440 - (55%) Gaps:63/440 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            |::|.|.:..|||.|.|..||:|.|:||:.:||:||:::.::.::: :.||.||:|.:|:..|||
Mouse    15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN-LEKIYREVQIMKMLDHPH 78

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||:.|.|.::::.||...||:|||:..||:|.|.:|||.|.||:|.|||||...:|||||
Mouse    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDL 143

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            |.||||||:||::||||||..|....||.|.|.||||.||||||..|:.|.||::||||.||:||
Mouse   144 KAENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            .|:||.||||...:|.|.:::..|.|.||.::::...:|:.:||.:||.||.:|.:||:|:|...
Mouse   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLI 273

  Fly   283 DLPA---YLFPSSIEQDSNVID-TYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNK 343
            ::|.   .|:|...|.:.::.: ...|..:....|:.:.:...| |....::..|..|.|:::..
Mouse   274 EVPVQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVES-LQNKSYNHFAAIYFLLVERL 337

  Fly   344 RFADDAANQINEINNFFVAGSPPPPPPPPVPQ---------SSMDHQAPLATVTVGGGTSASSGT 399
            :         :..::|            ||.|         |::..|......|||         
Mouse   338 K---------SHRSSF------------PVEQRLDGRQRRPSTIAEQTVAKAQTVG--------- 372

  Fly   400 ATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTA 449
                           :|:..||..:..||...|.   |.|...||...|:
Mouse   373 ---------------LPVTLHPPNVRLMRSTLLP---QASNVEAFSFPTS 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 129/254 (51%)
UBA_AID_AMPKalpha 297..360 CDD:270521 7/63 (11%)
AMPKA_C 457..580 CDD:213378
Sik2NP_848825.2 STKc_SIK 19..271 CDD:270973 128/252 (51%)
UBA_SIK2 297..341 CDD:270592 7/53 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..586
RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269|PubMed:29211348 595..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..662
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 798..842
Blue background indicates that the domain is not in the aligned region.

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