DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AMPKalpha and SIK3

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001353615.1 Gene:SIK3 / 23387 HGNCID:29165 Length:1369 Species:Homo sapiens


Alignment Length:469 Identity:169/469 - (36%)
Similarity:250/469 - (53%) Gaps:68/469 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AAAAEAVAAG-------SANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQK 63
            |.||.:.|||       ::.|....:||:|.:..|:|.|.|..||...|.:|:.|||:||:::.:
Human    37 APAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQ 101

  Fly    64 IKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQA 128
            :.. :.:.||.||:|.:|:..|||||:||||:.|...|:::.||.||||:||::|.||::.|.:|
Human   102 LDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA 165

  Fly   129 RRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAA 193
            ||.|:||::.|.:||...|||||||.||||||.|:::||||||.||:...|:.|:|.||||.|||
Human   166 RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA 230

  Fly   194 PEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVC 258
            ||:..||.|.||:|||||.||:||.|:||.||||...:..|..::.||.|.||.:::.:..:|:.
Human   231 PELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIR 295

  Fly   259 QMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAE-------------VCT 310
            .||.:||.||.::|:|.||:|.:      |..:....|..:.:...:.|             ...
Human   296 HMLVLDPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAME 354

  Fly   311 KFGVKETEVHNSLLSGDPHDQLAIAYHLIID-NKRFADDAANQINEINNFFVAGSPPPPPPPPVP 374
            ..|:.:.:...||.| |.:|..:..|.|:.| :||            :.....|:.|..|     
Human   355 DMGLDKEQTLQSLRS-DAYDHYSAIYSLLCDRHKR------------HKTLRLGALPSMP----- 401

  Fly   375 QSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTI-------------PIRPHPERIAP 426
             .::..|||:.......||:.:    ..||.|....|.:.|             ...|.||.:. 
Human   402 -RALAFQAPVNIQAEQAGTAMN----ISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALV- 460

  Fly   427 MRDRQLAMSVQTSG 440
               |.|:|...|.|
Human   461 ---RYLSMRRHTVG 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 126/254 (50%)
UBA_AID_AMPKalpha 297..360 CDD:270521 12/76 (16%)
AMPKA_C 457..580 CDD:213378
SIK3NP_001353615.1 STKc_SIK 65..317 CDD:270973 124/252 (49%)
UBA_SIK3 346..390 CDD:270593 11/56 (20%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.