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Protein Alignment AMPKalpha and Mark1

DIOPT Version :10

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001365805.1	Gene:	Mark1 / 226778	MGIID:	2664902	Length:	796	Species:	Mus musculus

Alignment Length:	660	Identity:	196/660 - (29%)
Similarity:	301/660 - (45%)	Gaps:	175/660 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIK 65
            :|:.|.:...|     .:.||  .||:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.
Mouse    40 LPRCRNSITSA-----TDEQP--HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN 97

  Fly    66 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARR 130
            ... :.|:.||::.:|:..||:|:||::||.|...::::|||.||||:|||:|.||:::|.:||.
Mouse    98 PTS-LQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 161

  Fly   131 FFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPE 195
            .|:||:|.|.|||:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||
Mouse   162 KFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226

  Fly   196 VISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQM 260
            :..||.|.|||||:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.::
Mouse   227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKL 291

  Fly   261 LQVDPLKRANIEEIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVH 320
            |.::|:||.::|:|.|..|.     :::|..|..|.....|:..||      :....|....|::
Mouse   292 LVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLSDAKRID------IMVTMGFARDEIN 350

  Fly   321 NSLLSGDPHDQLAIAY----------------------------------------HLIID---- 341
            ::|:| ..:|::...|                                        ||.:.
Mouse   351 DALVS-QKYDEVMATYILLGRKPPEFEGGESLSSGSLCQRSRPSSDLNNSTLQSPAHLKVQRSIS 414

  Fly   342 ----NKRFADDAANQINEINNFFVAGSPPPPPPPPV-----PQSS-----------MDHQAPLAT 386
                .:||:|.|.                |..||.|     ||::           .|....|.:
Mouse   415 ANQKQRRFSDHAG----------------PSIPPAVSYTKRPQANSVESEQKEEWGKDTARRLGS 463

  Fly   387 VTVGG----------GTSASSGTATPVPPV-AGGTPS--STIPIRPHPERIAPM---RDRQL--- 432
            .|||.          |......||:|...| :||:.:  :|.......:|.|.:   ||..|
Mouse   464 TTVGSKSEVTASPLVGPDRKKSTASPSNNVYSGGSMARRNTYVCERSTDRYAALQNGRDSSLTEM 528

  Fly   433 ---AMS-----VQTSGGGAFP---EKTARGGTPIK------------------------------ 456
               :||     |.::|..|.|   :..:..|.|||
Mouse   529 SASSMSSAGSTVASAGPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGSAAQRVPAASPSAH 593

  Fly   457 --------RAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYH----VRVRRQNVKTGKFS 509
                    |.::..|..|:|..:.   |..|..::.:|.....:|.|    ....|:...||..|
Mouse   594 SISASTPDRTRFPRGSSSRSTFHG---EQLRERRSAAYNGPPASPSHETGAFAHARRGTSTGIIS 655

  Fly   510 KMSLQLYQVD 519
            |::.:..:.|
Mouse   656 KITSKFVRRD 665

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.