DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and K02E10.7

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001360081.1	Gene:	K02E10.7 / 186892	WormBaseID:	WBGene00019321	Length:	609	Species:	Caenorhabditis elegans

Alignment Length:	342	Identity:	85/342 - (24%)
Similarity:	153/342 - (44%)	Gaps:	22/342 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTP 98
            :.:|.||.|.:|....:.::||:|..:.....::.........:|.:....||.|::.:.|....
Worm    56 IASGRFGTVFLGTITDSMLQVAIKEYHETFHDAVLTAHDEGSTLQKIISIEHPAIVQTFSVSHFQ 120

  Fly    99 SDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNM 163
            ..::.:||:.| ..|.|.|:..||..|.|.:....|....::|.|...:.|..|..:|:.|..||
Worm   121 DIVYKVMEFHS-WTLHDDILDKGKYDESQTKLVLVQATRALEYLHAQNLCHGTLHTKNIFLQENM 184

  Fly   164 HVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDD 228
             |||:|...|..:....|.:|......:.|||:.:.......|.|:||.||.::.:..|:.||..
Worm   185 -VKISDIESSQFLNWLPFSQTPLHILPFIAPELHNQLSEVTSECDLWSLGVCIFVMATGSCPFIL 248

  Fly   229 EHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSI 293
            |...|:...|::||...|...:.::.:||.|::.|:|.:|.:::.:.:.:|...||....|.|..
Worm   249 ESRNTMMESIQAGILGSPVLASDKIQSLVEQLIHVNPSERMSLKSLIEDDWMTSDLVWNYFISCH 313

  Fly   294 E---QDSNVIDTYAVAEVCTKFGVK--------ET--EVHNSLLSGDPHDQLAIAYHLIID---- 341
            |   ::..|:|.:..||...|..|:        ||  |.:.|:.|..|.:........::.
Worm   314 EDLIRELPVVDRFIPAESLEKSTVQRDGSEISIETLDEGYKSVASDHPEEPAVSGEQQVLTEPVP 378

  Fly   342 ---NKRFADDAANQINE 355
               :|:||..|...:.:
Worm   379 KKYHKKFAVFAMENVRK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	63/245 (26%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	16/76 (21%)
		AMPKA_C	457..580	CDD:213378
K02E10.7	NP_001360081.1	S_TKc	52..300	CDD:214567	63/245 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910