Protein Alignment AMPKalpha and aak-2

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_510710.2
• Gene: aak-2 / 181727
• WormBaseID: WBGene00020142
• Length: 626
• Species: Caenorhabditis elegans
• Alignment Length: 611
• Identity: 339/611 - (55%)
• Similarity: 395/611 - (64%)
• Gaps: 117/611 - (19%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            :|||||:|..|||.|||||||:|.|:.|:.||||||||||||||||||||||||||||.||||||
 Worm    82 IKIGHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRHPH 146

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            ||:||||||||||||||||:||||||||||||||:|:..:|||||||||||||||||||:|||||
 Worm   147 IIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDL 211

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||||||...:||||||||||:|.||:||||||||||||||||||||||||||||:||||||||
 Worm   212 KPENLLLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILY 276

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            |||||||||||||||:||||||||:||.|::|.:.:|||:..||.|||:|||.|:::..||||||
 Worm   277 ALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQK 341

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVC--TKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRF 345
            |||.||||...|.:::::|..||.||.  .::.|.|.||.::||..|||..|:|||:||:||||.
 Worm   342 DLPNYLFPPINESEASIVDIEAVREVTEFQRYHVAEEEVTSALLGDDPHHHLSIAYNLIVDNKRI 406

  Fly   346 ADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGT 410
            ||:.|..  .|..|:                         .||...|..
 Worm   407 ADETAKL--SIEEFY-------------------------QVTPNKGPG---------------- 428

  Fly   411 PSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIML 475
                 |:..|||||        |.||.:..........|.|....|||||||||||||:|.|||.
 Worm   429 -----PVHRHPERI--------AASVSSKITPTLDNTEASGANRNKRAKWHLGIRSQSRPEDIMF 480

  Fly   476 EVYRAMKALSYEWKIINPYHVRVRRQ-NVKTGKFSKMSLQLYQVDAKSYLLDFKSLTND------ 533
            ||:||||.|..|||::|||||.|||: :.......||||||||||.:|||||||||.::
 Worm   481 EVFRAMKQLDMEWKVLNPYHVIVRRKPDAPAADPPKMSLQLYQVDQRSYLLDFKSLADEESGSAS 545

  Fly   534 ---------------------------------------EVEQGDDVIMESLTPPPLSVSGVMPL 559
                                                   ||....|:..: :||||
 Worm   546 ASSSRHASMSMPQKPAGIRGTRTSSMPQAMSMEASIEKMEVHDFSDMSCD-VTPPP--------- 600

  Fly   560 QPTG---HHTMEFFEMCAALIIQLAR 582
            .|.|   ..||:|||:|||||..|||
 Worm   601 SPGGAKLSQTMQFFEICAALIGTLAR 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	207/254 (81%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	28/64 (44%)
		AMPKA_C	457..580	CDD:213378	72/171 (42%)
aak-2	NP_510710.2	STKc_AMPK_alpha	84..339	CDD:270981	207/254 (81%)
		S_TKc	87..339	CDD:214567	204/251 (81%)
		UBA_AID_AMPKalpha	356..419	CDD:270521	28/64 (44%)
		AMPKA_C	462..624	CDD:213378	72/171 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I302
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4551
Inparanoid	1	1.050	610	1.000	Inparanoid score	I495
Isobase	1	0.950	-	0	Normalized mean entropy	S655
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275232at33208
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		oto18316
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.050