Protein Alignment AMPKalpha and sad-1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001076760.1
• Gene: sad-1 / 181471
• WormBaseID: WBGene00004719
• Length: 914
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 202/590 - (34%)
• Similarity: 294/590 - (49%)
• Gaps: 116/590 - (19%)

  Fly    26 GHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIK 90
            |.|.|..|||.|..|.||.|.|.||..|||:||:|::|: |..|:.|:.|||..:||..|||::.
 Worm    45 GPYKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKL-SESVLQKVEREIAIMKLIEHPHVLH 108

  Fly    91 LYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPE 155
            ||.|......:::::|:|||||||||:|:.|:|...:||:||:||||.:|:||.|.|.|||||||
 Worm   109 LYDVYENKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPE 173

  Fly   156 NLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALL 220
            |||||...::|:||||::::.::|..|.||||||:||.||||.|:.|.|.:.|:|||||||||||
 Worm   174 NLLLDERNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 238

  Fly   221 CGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF----- 280
            .|.|||||:::..|..|:|.|:|.||.::...|.:|:..|::|||.||.::.::.||.|.
 Worm   239 VGALPFDDDNLRNLLEKVKRGVFHIPHFVPADVQSLLRAMIEVDPGKRYSLADVFKHPWVSGTTK 303

  Fly   281 ---QKDLP------AYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAY 336
               :.:||      .::.|.....|.:|: .:.....|.|   .:.::.|.||| ..|:...:.|
 Worm   304 ADPELELPMSQVVQTHVIPGEDSIDPDVL-RHMNCLGCFK---DKQKLINELLS-PKHNTEKMVY 363

  Fly   337 HLIIDNKR----FADD------AANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGG 391
            .|::|.||    ..||      .|.|.|:             ||.....||...:.|:.::..|.
 Worm   364 FLLLDRKRRRPAQEDDTEIVLRGAAQNND-------------PPKKRTDSSRTSRYPMGSIADGS 415

  Fly   392 --------GTSASSGTATPVPPVAGGTP-----SSTIPIRPHPERIAPMRDRQLAMSVQTSGGGA 443
                    |.:..||..:.:    ||:|     |||               |.|..|   |..|:
 Worm   416 PINPRKTYGRNQKSGRHSSL----GGSPTESPRSST---------------RDLFGS---SSSGS 458

  Fly   444 FPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPY-------HVR---V 498
            :   :||.|....|.      ||.|          |:..:..|..:.::|.       |||   .
 Worm   459 Y---SARAGEDRDRG------RSAS----------RSTNSYHYYTQPVDPQTLAEAARHVRDAQE 504

  Fly   499 RRQNVKTGKFS--KMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPLQP 561
            ||::..:|:.|  |.|.......|.|     .|..||  ......:....:||.:....|:....
 Worm   505 RRESRDSGRGSSRKESKDRSDKSASS-----SSCKND--ASSTSSVPHKYSPPSVMSESVVVSSS 562

  Fly   562 TGHHT 566
            |.:.|
 Worm   563 TMNST 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	130/253 (51%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	18/72 (25%)
		AMPKA_C	457..580	CDD:213378	26/122 (21%)
sad-1	NP_001076760.1	STKc_BRSK1_2	45..298	CDD:270983	130/253 (51%)
		UBA_BRSK	327..379	CDD:270525	14/56 (25%)