DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPKalpha and kin-29

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_508493.1	Gene:	kin-29 / 180574	WormBaseID:	WBGene00002210	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	169/695 - (24%)
Similarity:	285/695 - (41%)	Gaps:	192/695 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHP 86
            |.|||.|.:|..:|.|.|..|:|..|:|.:.|||:|.::...:...::: |:.||::.:|:..||
Worm    10 LEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLI-KLEREVKIVKVIDHP 73

  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            ||:|.|:::...:.::::.||.|.|||::.:::.|::.|:.||::|.:..|.|.|.|...|||||
Worm    74 HIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRD 138

  Fly   152 LKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVIL 216
            ||.||:||..|.::||.|||.||.....:.|.|.||||.|||||::.|..|.|.:.||||.||:|
Worm   139 LKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLL 203

  Fly   217 YALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF- 280
            |.|:.|..||..:.|..|.|.:.||:..||.:::.:..:.:.:||.::|.||..|:.:.:|.|.
Worm   204 YILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMH 268

  Fly   281 -----QKDLPAYL---FPSS---IEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAI 334
                 ||:..|.|   .|||   |.|.|..::...:..:.......|.::.:::|..|....:..
Worm   269 IRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFA 333

  Fly   335 AYHLIID----------NKRF-----------------------------------------ADD 348
            .|.|:.|          .:.|                                         :||
Worm   334 TYELLADKVKKGTLEGTGEEFPRRGSRGSILSGKANVDEQPLTPTISAHQLAQLNLSSPDCDSDD 398

  Fly   349 AANQ-------------------------INEINNFF-----------------VAGSPPPP--- 368
            ::|.                         ::.|.|.|                 :.|..|||
Worm   399 SSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLCASEQLLSPNMMGQFPPPNLL 463

  Fly   369 -------PP---PPVPQSSMD-------HQAPLATVTVG----------GGTSASSGTA------ 400
                   ||   ||:|:....       |.| .||:.:.          ....||:|..
Worm   464 LNNFSMNPPLGFPPMPEGQAAEFPLPSLHPA-FATIPIADLSKMLPVPKSERRASAGETLLPTNF 527

  Fly   401 --------TPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFP----EKTARGGT 453
                    .|.||::  .|:.....:.:..:....|:....:..|..||...|    ::|.....
Worm   528 DLTQHLANLPAPPIS--FPTVEEEGKSYLSKYGGKRNTVHCLGNQLGGGIQNPIPRYQRTPYTKA 590

  Fly   454 P--IKRAKW-----------HLG--IRSQSKPNDIMLEVYRAMKALSY----------------- 486
            |  .:|:.|           ||.  .:...:.|:.|..:::..|.||:
Worm   591 PPAERRSSWASPSLSAQQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSSLACP 655

  Fly   487 EWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLT 531
            :..|.:.|:   |:.|:.....|...:.::|.:|:..:...:..|
Worm   656 QISITDEYN---RQHNIAPSASSFDPVSIFQKNAQEVVFGQRPAT 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	99/254 (39%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/138 (9%)
		AMPKA_C	457..580	CDD:213378	17/105 (16%)
kin-29	NP_508493.1	PKc_like	16..267	CDD:304357	97/251 (39%)
kin-29	NP_508493.1	S_TKc	16..267	CDD:214567	97/251 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910