Protein Alignment AMPKalpha and kin-29

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_508493.1
• Gene: kin-29 / 180574
• WormBaseID: WBGene00002210
• Length: 822
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 169/695 - (24%)
• Similarity: 285/695 - (41%)
• Gaps: 192/695 - (27%)

  Fly    22 LVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHP 86
            |.|||.|.:|..:|.|.|..|:|..|:|.:.|||:|.::...:...::: |:.||::.:|:..||
 Worm    10 LEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLI-KLEREVKIVKVIDHP 73

  Fly    87 HIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRD 151
            ||:|.|:::...:.::::.||.|.|||::.:::.|::.|:.||::|.:..|.|.|.|...|||||
 Worm    74 HIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRD 138

  Fly   152 LKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVIL 216
            ||.||:||..|.::||.|||.||.....:.|.|.||||.|||||::.|..|.|.:.||||.||:|
 Worm   139 LKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLL 203

  Fly   217 YALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF- 280
            |.|:.|..||..:.|..|.|.:.||:..||.:::.:..:.:.:||.::|.||..|:.:.:|.|.
 Worm   204 YILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMH 268

  Fly   281 -----QKDLPAYL---FPSS---IEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAI 334
                 ||:..|.|   .|||   |.|.|..::...:..:.......|.::.:::|..|....:..
 Worm   269 IRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFA 333

  Fly   335 AYHLIID----------NKRF-----------------------------------------ADD 348
            .|.|:.|          .:.|                                         :||
 Worm   334 TYELLADKVKKGTLEGTGEEFPRRGSRGSILSGKANVDEQPLTPTISAHQLAQLNLSSPDCDSDD 398

  Fly   349 AANQ-------------------------INEINNFF-----------------VAGSPPPP--- 368
            ::|.                         ::.|.|.|                 :.|..|||
 Worm   399 SSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLCASEQLLSPNMMGQFPPPNLL 463

  Fly   369 -------PP---PPVPQSSMD-------HQAPLATVTVG----------GGTSASSGTA------ 400
                   ||   ||:|:....       |.| .||:.:.          ....||:|..
 Worm   464 LNNFSMNPPLGFPPMPEGQAAEFPLPSLHPA-FATIPIADLSKMLPVPKSERRASAGETLLPTNF 527

  Fly   401 --------TPVPPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFP----EKTARGGT 453
                    .|.||::  .|:.....:.:..:....|:....:..|..||...|    ::|.....
 Worm   528 DLTQHLANLPAPPIS--FPTVEEEGKSYLSKYGGKRNTVHCLGNQLGGGIQNPIPRYQRTPYTKA 590

  Fly   454 P--IKRAKW-----------HLG--IRSQSKPNDIMLEVYRAMKALSY----------------- 486
            |  .:|:.|           ||.  .:...:.|:.|..:::..|.||:
 Worm   591 PPAERRSSWASPSLSAQQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSSLACP 655

  Fly   487 EWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLT 531
            :..|.:.|:   |:.|:.....|...:.::|.:|:..:...:..|
 Worm   656 QISITDEYN---RQHNIAPSASSFDPVSIFQKNAQEVVFGQRPAT 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	99/254 (39%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/138 (9%)
		AMPKA_C	457..580	CDD:213378	17/105 (16%)
kin-29	NP_508493.1	Protein Kinases, catalytic domain	16..267	CDD:473864	97/251 (39%)