Protein Alignment AMPKalpha and kin-34

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_503162.3
• Gene: kin-34 / 178552
• WormBaseID: WBGene00019815
• Length: 311
• Species: Caenorhabditis elegans
• Alignment Length: 287
• Identity: 94/287 - (32%)
• Similarity: 149/287 - (51%)
• Gaps: 37/287 - (12%)

  Fly    34 LGTGTFGKVK-IGEHQITRVKVAVK--ILNRQKIKSLDVVGKIRREIQ-NLKLFRHPHIIKLYQV 94
            ||.|:||:|. :...:...:..|:|  ::..|..:.:|.   ||:||. ...|..|.::|   ||
 Worm    31 LGQGSFGQVALVSNRRYPEMLAALKRIVITGQDREYIDA---IRKEITIQESLTGHENVI---QV 89

  Fly    95 ISTPSD---IFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            :...||   .:|.:||..||:|::.|.........:|..:|:|:::|:.:.|...:.|||:||||
 Worm    90 LGKESDAQFCYMFLEYADGGDLYEKITSGCSFSLEEAHSYFKQLVNGLKFLHCRDVAHRDIKPEN 154

  Fly   157 LLLDHNMHVKIADFGLSN--MMLDGEFL-RTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYA 218
            |:|.|:.|:|||||||:.  .....|.: ...|||..|.|||:.:|..|.||::||||.||:|.|
 Worm   155 LMLTHSGHLKIADFGLATWYRYKGAELIFEQRCGSVEYVAPEIYTGAQYRGPQIDIWSAGVVLLA 219

  Fly   219 LLCGTLPFDDEHVPTLFRK-----IKSGIFPIPEY--LNKQVVNLVCQMLQVDPLKRANIEEIKK 276
            :|...||::   .|.:..|     :|:.:..|..:  |:.:...|:.:||......||.||||:.
 Worm   220 MLTRQLPWE---FPCMTNKRYFFWMKNRVAHIDAWNELSCRAKKLLWKMLSPGSENRATIEEIQS 281

  Fly   277 HEWFQKDLPAYLF----PSSIEQDSNV 299
            ..|       |||    ...::.|.|:
 Worm   282 SAW-------YLFGDVENDEVDDDDNL 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	88/262 (34%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	1/3 (33%)
		AMPKA_C	457..580	CDD:213378
kin-34	NP_503162.3	Protein Kinases, catalytic domain	24..285	CDD:473864	89/269 (33%)