Protein Alignment AMPKalpha and txt-2

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_872128.2
• Gene: txt-2 / 178551
• WormBaseID: WBGene00019817
• Length: 328
• Species: Caenorhabditis elegans
• Alignment Length: 268
• Identity: 94/268 - (35%)
• Similarity: 151/268 - (56%)
• Gaps: 32/268 - (11%)

  Fly    34 LGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK-------IRREI---QNLKLFRHPHI 88
            ||.|:|.:|.:    :.:|....|:.   .:|.:.:|||       |:||.   :.|...||.::
 Worm    28 LGEGSFAEVVL----VAKVGTPNKMF---AMKEISIVGKDECFMESIKRECSIQKRLSKSRHLNM 85

  Fly    89 IKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLK 153
            |.|:::.:.|.:..:|:.|..||:||:.|.:||.|...:|.|:|:|:|.|:.:.|...:.|||:|
 Worm    86 IHLFEIRTNPENYQLILSYADGGDLFEKINQHGGLGSDEAHRYFKQLIDGLRFIHEEGVTHRDIK 150

  Fly   154 PENLLLDHNMHVKIADFGLSNM-MLDG--EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVI 215
            ||||||..:..:||||||.:.| ..:|  :.|...||||.|.||||::|..|.||.|||||.||:
 Worm   151 PENLLLTKSGILKIADFGFATMHRFNGAEQMLNAYCGSPPYIAPEVLTGIDYRGPAVDIWSAGVV 215

  Fly   216 LYALLCGTLPFDDEHVPTLF--------RKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIE 272
            |.|::.|.:|::......:|        |..:.|.:   ..:::||::|:.::|....| ||.|.
 Worm   216 LIAMIAGAVPWEQADHFDIFQSRYCSFRRNGRKGAW---SRMSQQVISLLRKILLQAEL-RATIS 276

  Fly   273 EIKKHEWF 280
            .|::..||
 Worm   277 MIEEDPWF 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	92/266 (35%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
txt-2	NP_872128.2	Protein Kinases, catalytic domain	22..284	CDD:473864	92/266 (35%)