Protein Alignment AMPKalpha and R02C2.1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_503161.2
• Gene: R02C2.1 / 178550
• WormBaseID: WBGene00019814
• Length: 312
• Species: Caenorhabditis elegans
• Alignment Length: 286
• Identity: 101/286 - (35%)
• Similarity: 151/286 - (52%)
• Gaps: 37/286 - (12%)

  Fly    37 GTFGKVKIGEHQITR---VKVAVK--ILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVIS 96
            |:||:|.:.|  :||   ||||||  .::.:..|:|..|.|..:..:.|....|.::|::.::|.
 Worm    27 GSFGQVHLCE--LTRNPSVKVAVKEVAVSGKSRKNLTAVQKEYKIHRRLSKIGHENVIQMMKMIE 89

  Fly    97 TPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLL-- 159
            ||....::|||..||:|||.:.:..|.....|..:|:|:|.|:.:.|...|||||:|.|||||
 Worm    90 TPKFYSLVMEYADGGDLFDELKEQEKFSRKDAHSYFKQLIKGLKFIHEQGIVHRDIKLENLLLVY 154

  Fly   160 ----DHNMHVKIADFGL-SNMMLDGE--FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
                |....:||.|||| :....|||  .|...|||..||||||.:|..|.||.|||||.||:|.
 Worm   155 SESEDDPGTLKITDFGLATKYRKDGEEIMLSEDCGSKPYAAPEVCTGNDYRGPPVDIWSAGVVLM 219

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQ--------VVN-----LVCQMLQVDPLKRA 269
            .:|.|      ||...:..|.|...:  ..::|.:        |::     |:.::|..:|.|||
 Worm   220 TMLVG------EHSWKVANKEKDAAY--SNWINAKDEKANLWNVISGPTTALLRKLLHANPEKRA 276

  Fly   270 NIEEIKKHEWFQKDLPAYLFPSSIEQ 295
            .:.:|:...||:.:....:.|.|.|:
 Worm   277 TMAKIEADPWFRYNYGKRVVPKSEEE 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	96/269 (36%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
R02C2.1	NP_503161.2	Protein Kinases, catalytic domain	16..287	CDD:473864	96/269 (36%)