Protein Alignment AMPKalpha and kin-33

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001367716.1
• Gene: kin-33 / 178549
• WormBaseID: WBGene00017083
• Length: 337
• Species: Caenorhabditis elegans
• Alignment Length: 311
• Identity: 108/311 - (34%)
• Similarity: 144/311 - (46%)
• Gaps: 73/311 - (23%)

  Fly    13 AAGSANGQPLVKIGHYLLGATLGTGTFGKVKI-------------------GEH--QITRVKVAV 56
            |..|....|......|.:...||.||||||.:                   |||  |||
 Worm     3 ATESTTTTPPASTEKYQVLGLLGKGTFGKVLLIELESLPGEAVAMKEIEASGEHVEQIT------ 61

  Fly    57 KILNRQK----IKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYI 117
              ||.:|    .|.|...|             |.::|:...:.:.|...|:||||..||:|||.|
 Worm    62 --LNVKKEYILTKRLSAPG-------------HENVIRFLSIRTMPEHYFLIMEYADGGDLFDKI 111

  Fly   118 VKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNM-MLDGE- 180
            ....:|...||..:|:|:|:|:.|.|...:.|||:|||||:|.....:||.||||..: ::.||
 Worm   112 SSEYRLTSSQAHGYFKQLIAGLRYIHSKGVTHRDIKPENLMLTKAGVLKITDFGLGTLHIIKGEE 176

  Fly   181 -FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLP--------------FDDEH 230
             .:.|.||:|.||||||:.|..|.||.|||||.||:|..:|.|..|              |:||.
 Worm   177 SLMDTRCGTPQYAAPEVLVGNQYRGPPVDIWSAGVVLINMLTGHSPWKKACKSDASYTRWFNDEC 241

  Fly   231 VPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ 281
            ..   |...|.       |..:|:.|:|.:|..:|..||.||.|::..|||
 Worm   242 TE---RDAWSD-------LGARVITLLCSILAHNPTHRAPIELIEQDHWFQ 282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	102/296 (34%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
kin-33	NP_001367716.1	Protein Kinases, catalytic domain	16..281	CDD:473864	102/295 (35%)