Protein Alignment AMPKalpha and Y38H8A.4

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_502595.1
• Gene: Y38H8A.4 / 178314
• WormBaseID: WBGene00012638
• Length: 331
• Species: Caenorhabditis elegans
• Alignment Length: 269
• Identity: 98/269 - (36%)
• Similarity: 151/269 - (56%)
• Gaps: 19/269 - (7%)

  Fly    34 LGTGTFGKVKIGEHQITRVKVAVKILN----RQKIKSLDVVGK-IRREIQNLKLFRHPHIIKLYQ 93
            ||:|::.:|........:::||.|::|    |:|.   |.:.| :.||.:.:||.:|.::.:||:
 Worm    42 LGSGSYSRVARATWGDKKLEVAAKVINITPTREKD---DYIKKFLPREKEIVKLLKHDNVCRLYE 103

  Fly    94 VISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLL 158
            :||.|..|..:.|:.:||:|...:.|...:.|..|:..|:|.|:.:.:...:.|||||||.||:.
 Worm   104 MISFPDHIIFVTEFCAGGDLLRKMKKIKTMSEENAKFTFRQFIAALMHLQSYNIVHRDLKCENIF 168

  Fly   159 LDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGT 223
            ||...:||:.|||.|.::..||...|.|||..|.|||::.|:.|:|..||:||.|||||.:|.||
 Worm   169 LDKYENVKLGDFGFSRILKPGEKSGTFCGSRAYVAPEILRGREYSGNAVDVWSTGVILYIMLVGT 233

  Fly   224 LPFDDEHVPT------LFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            :||||.. ||      |..|||.|........:|.   |:.::||.....|...:.|.:.||. |
 Worm   234 MPFDDRD-PTRMIERQLAHKIKFGKTCTASIHSKA---LILEILQPHAPNRPTYKAICESEWL-K 293

  Fly   283 DLPAYLFPS 291
            :.|.|:.|:
 Worm   294 NQPYYMKPN 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	93/256 (36%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
Y38H8A.4	NP_502595.1	Protein Kinases, catalytic domain	38..292	CDD:473864	93/256 (36%)