DRSC/TRiP Functional Genomics Resources

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Protein Alignment AMPKalpha and Sik1

DIOPT Version :10

Sequence 1:NP_477313.1 Gene:AMPKalpha / 43904 FlyBaseID:FBgn0023169 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_034961.2 Gene:Sik1 / 17691 MGIID:104754 Length:779 Species:Mus musculus


Alignment Length:440 Identity:165/440 - (37%)
Similarity:243/440 - (55%) Gaps:59/440 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 AVAAGSANGQ--PLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKI 73
            ||.:|:..||  || ::|.|.:..|||.|.|..||:..|::|:.:||:||:::.::.|.: :.||
Mouse     9 AVPSGTGQGQQKPL-RVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN-LEKI 71

  Fly    74 RREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISG 138
            .||:|.:||..||:|||||||:.|...::::.|:...||:|||:..:|.|.|::||:.|.||:|.
Mouse    72 YREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSA 136

  Fly   139 VDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYA 203
            |:|||.|.|||||||.||||||.||.:|:||||..|....||.|.|.||||.||||||..||.|.
Mouse   137 VEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYE 201

  Fly   204 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKR 268
            ||::|:||.||:||.|:||:||||..::|||.:::..|.|.||.::::....|:.:||.|||.||
Mouse   202 GPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKR 266

  Fly   269 ANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYA-----------VAEVCTKFGVKETEVHNS 322
            ..|.:|::|.|.|.|      |:.::||....|...           |..:....|:.......|
Mouse   267 ITIAQIRQHRWMQAD------PTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIES 325

  Fly   323 LLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATV 387
             |....::..|..|:|:::  |..:..:.|         ..|.|.|.|...||.   ..:.|:::
Mouse   326 -LQNSSYNHFAAIYYLLLE--RLKEHRSAQ---------PSSRPTPAPTRQPQL---RSSDLSSL 375

  Fly   388 TVGGGTSASSGTATPVPPVAGGTPSSTIPIRP-HPERIAPMRDRQLAMSV 436
            .|                     |...:|..| .|..:.| :.:.||.||
Mouse   376 EV---------------------PQEILPCDPFRPSLLCP-QPQALAQSV 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AMPKalphaNP_477313.1 STKc_AMPK_alpha 25..280 CDD:270981 125/254 (49%)
UBA_AID_AMPKalpha 297..360 CDD:270521 10/73 (14%)
AMPKA_C 457..580 CDD:213378
Sik1NP_034961.2 STKc_SIK 26..278 CDD:270973 124/252 (49%)
UBA_SIK1 300..349 CDD:270591 8/51 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..375 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..472
RK-rich region 586..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..641
Blue background indicates that the domain is not in the aligned region.

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