DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and pig-1

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001294353.1	Gene:	pig-1 / 176877	WormBaseID:	WBGene00021012	Length:	706	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	165/524 - (31%)
Similarity:	253/524 - (48%)	Gaps:	87/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIK 90
            |.|.:...||:|.||||::..|.:|..|||:||::::::.  ..:.:::.|:..|:...|.:|.:
Worm     9 GFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLG--HDLPRVQTEMDALRNLSHQNICR 71

  Fly    91 LYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPE 155
            ||..|.|....|::|||.||||:|||||:..:|:|.:||.||:|::|.:.:.|.....|||||||
Worm    72 LYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPE 136

  Fly   156 NLLLDHNMHVKIADFGL----SNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVIL 216
            ||||..::|:|:.||||    ....:|...|.|.||||.|||||:|.|..|.|.|.|:||.|::|
Worm   137 NLLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPELIQGLQYKGNEADVWSMGILL 201

  Fly   217 YALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQ 281
            |.||.|.|||:|:::..:::||:||.|..||:|:.....|:..||||.|.:|.:::::.:|:|..
Worm   202 YTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLN 266

  Fly   282 KDLPAYLFPSSIEQDSNVIDTYAVAEVCTK-FGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKR- 344
            ......:..::| .|.|.||. .||.|.:| :|.:.|:.....:.....|.:...|:.::..||
Worm   267 HKYTQPVKWNTI-YDKNFIDR-DVARVMSKYYGFESTDKMIEKIKEWNFDYMTSTYYALLHRKRN 329

  Fly   345 -----------FADDAANQINEI-----------NNFFVAGSPPPPPPPPVPQSSMDHQAPLATV 387
                       ..:.|...:..|           ||...:|.......|....||.|..|.|...
Worm   330 GMEIILPMVRNSTNTAPPNVQNILCSPTIHASLENNLDKSGLEDDDSDPSSISSSSDISARLKKN 394

  Fly   388 TVGGGTSASSGTATPVPPVA--GGTPSSTIPIRPHPERI---APMRDRQLAMSVQTS-----GGG 442
            .|....|:||....|:.|.|  ....|....:...|.:.   :|:|..:..|||::|     |..
Worm   395 CVVSDESSSSRFVKPMSPAAEKDKKMSYVNAMLTMPSQFTGRSPLRIPESPMSVRSSDSASLGSA 459

  Fly   443 AFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGK 507
            |.|   :|||.               |.||                           ::|..|||
Worm   460 ATP---SRGGV---------------KDND---------------------------KENASTGK 479

  Fly   508 FSKM 511
            ..:|
Worm   480 NYRM 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	109/257 (42%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	17/86 (20%)
		AMPKA_C	457..580	CDD:213378	8/55 (15%)
pig-1	NP_001294353.1	STKc_MELK	7..265	CDD:270980	109/257 (42%)
		S_TKc	11..265	CDD:214567	108/255 (42%)
		UBA_MELK	284..335	CDD:270526	12/51 (24%)
		MELK_C	611..703	CDD:213383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910