Protein Alignment AMPKalpha and aak-1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_741254.3
• Gene: aak-1 / 176230
• WormBaseID: WBGene00019801
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 635
• Identity: 258/635 - (40%)
• Similarity: 343/635 - (54%)
• Gaps: 144/635 - (22%)

  Fly    14 AGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQ 78
            ||:.:    :|||::::..|:|.|.||.||.|.|..|...||:|||||.::|.|..|.|.|.||.
 Worm    14 AGTGH----LKIGNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEID 74

  Fly    79 NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCH 143
            ||:...||||.:|::|||||||||::||.|||||||.||.:.|.|...::||:||||||||.|||
 Worm    75 NLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCH 139

  Fly   144 RHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208
            .||||||||||||||||.|.::|||||||||.|.||:.|.|:||||||||||:||.|||.|||||
 Worm   140 NHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGPEVD 204

  Fly   209 IWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE 273
            :|||||||||:|||||||||::|||||.|||||.:.:|..:.||..:|:..||||||:|||:::.
 Worm   205 LWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSMEKQAADLISTMLQVDPVKRADVKR 269

  Fly   274 IKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHL 338
            |..|.||:.|||.|||| ..|.:|:::|...|..|..||.|||.:|..:||:.|.|..|.|||.|
 Worm   270 IVNHSWFRIDLPYYLFP-ECENESSIVDIDVVQSVAEKFDVKEEDVTGALLAEDHHHFLCIAYRL 333

  Fly   339 IIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPV 403
            .:::||.||:::.:..|  :|:..|.                     |:.:|       .|:.||
 Worm   334 EVNHKRNADESSQKAME--DFWEIGK---------------------TMKMG-------STSLPV 368

  Fly   404 PPVAGGTPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQS 468
                |.|..:.:             .|::...::...               |:..|:||||:..
 Worm   369 ----GATTKTNV-------------GRKILEGLKKEQ---------------KKLTWNLGIRACL 401

  Fly   469 KPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFS-KMSLQLYQVDA----KSYLLDFK 528
            .|.:.|..|:.::|::..|||:::.||:.||.:........ |:||||:.:|.    |.||||||
 Worm   402 DPVETMKHVFLSLKSVDMEWKVLSMYHIIVRSKPTPINPDPVKVSLQLFALDKKENNKGYLLDFK 466

  Fly   529 SLTNDE------------------------------------------------------VEQGD 539
            .||.||                                                      |:..|
 Worm   467 GLTEDEEAVPPSRCRSRAASVSVTLAKSKSDLNGNSSKVPMSPLSPMSPISPSVNIPKVRVDDAD 531

  Fly   540 DVI----------------MESLTPPPLSVSGVMPLQPTGHHTMEFFEMC 573
            ..:                ||||  ..:|.....|..|....|||||..|
 Worm   532 ASLKSSLNSSIYMADIENSMESL--DEVSTQSSEPEAPIRSQTMEFFATC 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	162/254 (64%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	24/62 (39%)
		AMPKA_C	457..580	CDD:213378	48/192 (25%)
aak-1	NP_741254.3	PKc_like	21..276	CDD:304357	162/254 (64%)
		S_TKc	24..276	CDD:214567	160/251 (64%)
		UBA_AID_AMPKalpha	292..356	CDD:270521	25/65 (38%)
		AMPKA_C	390..>479	CDD:213378	33/88 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S655
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275232at33208
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.970