Protein Alignment AMPKalpha and mekk-3

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_492629.1
• Gene: mekk-3 / 172850
• WormBaseID: WBGene00013694
• Length: 430
• Species: Caenorhabditis elegans
• Alignment Length: 297
• Identity: 90/297 - (30%)
• Similarity: 141/297 - (47%)
• Gaps: 45/297 - (15%)

  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGK---IRREIQNLKLFRHPHII 89
            |.||..:|.||.|.|.:.|.: .....||||:::.        |:   ...:::.|::.||..|:
 Worm   157 YSLGKLIGRGTLGSVYLAEGK-KGGTYAVKIISKH--------GRHLPQEADVEYLRMLRHVRIV 212

  Fly    90 KLYQVI--STPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            :...:|  |..:||.::|||:..|.|.:||.:.|.|.....:.:.:||:.|:::.|...|:|:||
 Worm   213 EYLYIIEPSKSNDIHILMEYMHTGSLQEYIARTGPLHHELVKAYAKQILEGLEFLHSKNIIHQDL 277

  Fly   153 KPENLLLDHNMH----VKIADFGLSNMM-----LDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208
            ||.|||| .|.|    :||||||.|...     .:|:..||    |.|..|.|..|:..:|...|
 Worm   278 KPANLLL-KNTHRERLIKIADFGSSRFSSLKREREGQQGRT----PKYTDPGVSLGRHVSGRRSD 337

  Fly   209 IWSCGVILYALLCGTLPF--DDEHVPTLFRKIKSG--IFPIPEYLNKQVVNLVCQMLQVDPLKRA 269
            |||.|||:..:..|..|:  |.||..|:.|.:...  .|...|.:::.::.:...|||
 Worm   338 IWSLGVIIIEMYTGVYPWSIDGEHPITVPRILDENPPNFTTSEKIDENLIKMAKLMLQ------- 395

  Fly   270 NIEEIKKHEWFQKDLPAYLFPSSIE---QDSNVIDTY 303
               .:.|..:....|...:...|.|   :||:..|.|
 Worm   396 ---SVAKRPYASTLLELPILQESSENEDEDSDDDDDY 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	83/269 (31%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	3/7 (43%)
		AMPKA_C	457..580	CDD:213378
mekk-3	NP_492629.1	S_TKc	157..412	CDD:214567	84/278 (30%)