DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Melk

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_034920.2	Gene:	Melk / 17279	MGIID:	106924	Length:	643	Species:	Mus musculus

Alignment Length:	337	Identity:	139/337 - (41%)
Similarity:	195/337 - (57%)	Gaps:	22/337 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            :|.|..|:|||.|.|||:..|.:|...||:||:::..:.|  .:.:::.||..||..||.||.:|
Mouse    10 YYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLRHQHICQL 72

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            |.|:.|.:.|||::||..||||||||:...:|.|.:.|..|:||:|.|.|.|.....||||||||
Mouse    73 YHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPEN 137

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGE--FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||.|.|..:|:.||||.......:  .|:|.|||..|||||:|.||.|.|.|.|:||.|::||.|
Mouse   138 LLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL 202

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQKDL 284
            :||.|||||::|..|::||..|.:.:|::|:...:.|:.|||||||.||.::..:..|.|..:|
Mouse   203 MCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQD- 266

  Fly   285 PAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHN--------SLLSGDPHDQLAIAYHLIID 341
              |..|  :|..|....|: :.|.|    |.|..||:        .|:|...:|.|...|.|::.
Mouse   267 --YSCP--VEWQSKTPLTH-LDEDC----VTELSVHHRSSRQTMEDLISSWQYDHLTATYLLLLA 322

  Fly   342 NKRFADDAANQI 353
            .|.....|..|:
Mouse   323 KKARGKPARLQL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	117/254 (46%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	17/65 (26%)
		AMPKA_C	457..580	CDD:213378
Melk	NP_034920.2	STKc_MELK	7..263	CDD:270980	117/254 (46%)
		S_TKc	11..263	CDD:214567	117/253 (46%)
		UBA_MELK	281..332	CDD:270526	14/55 (25%)
		UBA-like. /evidence=ECO:0000250	282..321		12/42 (29%)
		Autoinhibitory region. /evidence=ECO:0000250	326..643		2/9 (22%)
		MELK_C	547..641	CDD:213383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910