Protein Alignment AMPKalpha and Mark3

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_006515574.1
• Gene: Mark3 / 17169
• MGIID: 1341865
• Length: 806
• Species: Mus musculus
• Alignment Length: 488
• Identity: 168/488 - (34%)
• Similarity: 252/488 - (51%)
• Gaps: 79/488 - (16%)

  Fly    14 AGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQ 78
            |..|:.||  .||:|.|..|:|.|.|.|||:..|.:|..:||:||:::.::.... :.|:.||::
Mouse    44 ASCADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVR 105

  Fly    79 NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCH 143
            .:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::|.:||..|:||:|.|.|||
Mouse   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 170

  Fly   144 RHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208
            :..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.|||||
Mouse   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 235

  Fly   209 IWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE 273
            :||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|:||..:|:
Mouse   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQ 300

  Fly   274 IKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLA 333
            |.|..|.     :.:|..::.|.....|...||      :....|..:.|:..| ||...:|::.
Mouse   301 IMKDRWINAGHEEDELKPFVEPELDISDQKRID------IMVGMGYSQEEIQES-LSKMKYDEIT 358

  Fly   334 IAYHLIIDNKRFADDAANQINEINNFFVA------------GSPPPPPPPPVPQSSM------DH 380
            ..|.|:  .::.|:..|:..:..:|..:|            |..|.........||.      ||
Mouse   359 ATYLLL--GRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDH 421

  Fly   381 QAPLATVTVGGGTSASSGTA------------------------TPVPPVAG--GTPSSTIPIRP 419
            ..|.....|.....:.:.||                        .|..|:.|  |.|:.
Mouse   422 AGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLGNAGNPNK------ 480

  Fly   420 HPERIAPMRDRQLAMSVQTSGGGAFPEKTARGG 452
                 |.:.:|:.:.:|.:|       .||.||
Mouse   481 -----ADIPERKKSPAVPSS-------NTASGG 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	123/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/62 (21%)
		AMPKA_C	457..580	CDD:213378
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	121/252 (48%)
		UBA_MARK3_4	325..367	CDD:270590	11/50 (22%)
		MARK1-3_C	707..804	CDD:213381