Protein Alignment AMPKalpha and Mark3

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_006240625.1
• Gene: Mark3 / 170577
• RGDID: 619883
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 477
• Identity: 169/477 - (35%)
• Similarity: 250/477 - (52%)
• Gaps: 68/477 - (14%)

  Fly    14 AGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQ 78
            |..|:.||  .||:|.|..|:|.|.|.|||:..|.:|..:||:||:::.::.... :.|:.||::
  Rat    44 ASCADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKLFREVR 105

  Fly    79 NLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCH 143
            .:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::|.:||..|:||:|.|.|||
  Rat   106 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 170

  Fly   144 RHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVD 208
            :..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.|||||
  Rat   171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 235

  Fly   209 IWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEE 273
            :||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|:||..:|:
  Rat   236 VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQ 300

  Fly   274 IKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLA 333
            |.|..|.     :::|..::.|.....|...||      :....|..:.|:..| ||...:|::.
  Rat   301 IMKDRWINAGHEEEELKPFVEPELDISDQKRID------IMVGMGYSQEEIQES-LSKMKYDEIT 358

  Fly   334 IAYHLIIDNKRFADDAANQINEINNFFVA------------GSPPPPPPPPVPQSSM------DH 380
            ..|.|:  .::.|:..|:..:..:|..:|            |..|.........||.      ||
  Rat   359 ATYLLL--GRKSAELDASDSSSSSNLSLAKVRPSSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDH 421

  Fly   381 QAPLATVTVG-----------------------GGTSASSGTA-TPVPPVAGGTPSSTIPIRPHP 421
            ..|.....|.                       .|:||..|.. .|..|:.|...:      |:.
  Rat   422 AGPAIPSVVAYPKRSQTSTADSDLKEDGVPSRKSGSSAVGGKGIAPASPMLGNASN------PNK 480

  Fly   422 ERIAPMRDRQLAM--SVQTSGG 441
            ..| |.|.:..|:  |...|||
  Rat   481 ADI-PERKKSPAVPSSNAASGG 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	123/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/62 (21%)
		AMPKA_C	457..580	CDD:213378
Mark3	XP_006240625.1	STKc_MARK	55..307	CDD:270974	121/252 (48%)
		UBA_MARK3_4	325..367	CDD:270590	11/50 (22%)
		MARK1-3_C	707..804	CDD:213381