DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and NIM1K

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_699192.1	Gene:	NIM1K / 167359	HGNCID:	28646	Length:	436	Species:	Homo sapiens

Alignment Length:	334	Identity:	122/334 - (36%)
Similarity:	185/334 - (55%)	Gaps:	29/334 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNR----QKIKSLDVVGKIRREIQNLKLFR 84
            :||.|.:...:|:|.|.:||:|.|.:|:.|||:|||::    ||.:.|     :.|||.:::...
Human    70 RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRL-----LSREISSMEKLH 129

  Fly    85 HPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVH 149
            ||:||:||:|:.|.|.:.::|||..|||||..|...|||.|.:::..|.||:|.|.:.|.:.|:|
Human   130 HPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQIIH 194

  Fly   150 RDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGV 214
            ||||.||:....|..||:.|||.|.:...||.|.|.||||.|||||:...:.|.|..||||:.||
Human   195 RDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWALGV 259

  Fly   215 ILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEW 279
            :||.::.||:||..|.|..|.:.|..|.:.:|.::::....|:..:||..|.:|..|:.|...||
Human   260 LLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGIDCIMNDEW 324

  Fly   280 ------------FQKDLPAYLF-PSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQ 331
                        ||.| |.:|. .|:::::.|     .|.......|:.|..:.|: ...|....
Human   325 MQGVPYPTPLEPFQLD-PKHLSETSTLKEEEN-----EVKSTLEHLGITEEHIRNN-QGRDARSS 382

  Fly   332 LAIAYHLII 340
            :...|.:|:
Human   383 ITGVYRIIL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	108/270 (40%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	8/44 (18%)
		AMPKA_C	457..580	CDD:213378
NIM1K	NP_699192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..55
		STKc_NIM1	71..325	CDD:270977	107/258 (41%)
		S_TKc	74..325	CDD:214567	105/255 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910