DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and Mark2

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_006526704.1	Gene:	Mark2 / 13728	MGIID:	99638	Length:	851	Species:	Mus musculus

Alignment Length:	490	Identity:	170/490 - (34%)
Similarity:	250/490 - (51%)	Gaps:	72/490 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREI 77
            :|.||:.||  .||:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.| ..:.|:.||:
Mouse    50 SATSADEQP--HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS-SSLQKLFREV 111

  Fly    78 QNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYC 142
            :.:|:..||:|:||::||.|...::::|||.||||:|||:|.||:::|.:||..|:||:|.|.||
Mouse   112 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 176

  Fly   143 HRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEV 207
            |:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:..||.|.||||
Mouse   177 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 241

  Fly   208 DIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIE 272
            |:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|.::|.||..:|
Mouse   242 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 306

  Fly   273 EIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQL 332
            :|.|..|.     ..:|..|:.|....:|..      ..|:....|....|:.:||: |..::::
Mouse   307 QIMKDRWMNVGHEDDELKPYVEPLPDYKDPR------RTELMVSMGYTREEIQDSLV-GQRYNEV 364

  Fly   333 AIAYHLIIDNKRFADDAANQINEINNFFVAGSPPP---------PPPP----------PVPQSSM 378
            ...|.|:          ..:.:|:....:...|.|         |.|.          |..:.|.
Mouse   365 MATYLLL----------GYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRSS 419

  Fly   379 DHQAPLATVTVGG-------------------GTSASSGTATPVPPVAGGTPSSTIPIRPHPERI 424
            |...| |..|...                   |..|||....|..|:.|.....|.|
Mouse   420 DQAVP-AIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKVPASPLPGLDRKKTTP-------- 475

  Fly   425 APMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAK 459
            ||..:..|:.|...|......::.:.|...|:..|
Mouse   476 APSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	124/254 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	9/62 (15%)
		AMPKA_C	457..580	CDD:213378	1/3 (33%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	122/252 (48%)
		UBA_MARK2	332..373	CDD:270589	9/57 (16%)
		MARK2_C	752..850	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910