Protein Alignment AMPKalpha and AMPKalpha

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_312237.4
• Gene: AMPKalpha / 1273276
• VectorBaseID: AGAMI1_005037
• Length: 565
• Species: Anopheles gambiae
• Alignment Length: 591
• Identity: 449/591 - (75%)
• Similarity: 480/591 - (81%)
• Gaps: 53/591 - (8%)

  Fly    15 GSANG---QPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRRE 76
            ||..|   |||||||||:||||||||:||||||||||:|:.||||||||||||||||||||||||
Mosquito     5 GSQPGGTPQPLVKIGHYILGATLGTGSFGKVKIGEHQVTKHKVAVKILNRQKIKSLDVVGKIRRE 69

  Fly    77 IQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDY 141
            ||||||||||||||||||||||:||||||||||||||||||||:|||||.:||||||||||||||
Mosquito    70 IQNLKLFRHPHIIKLYQVISTPTDIFMIMEYVSGGELFDYIVKNGKLQESEARRFFQQIISGVDY 134

  Fly   142 CHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPE 206
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Mosquito   135 CHRHMIVHRDLKPENLLLDHNRHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPE 199

  Fly   207 VDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANI 271
            |||||||||||||||||||||||||||||||||||:||||||||||||:|:||||||||||||.:
Mosquito   200 VDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGVFPIPEYLNKQVVSLLCQMLQVDPLKRATV 264

  Fly   272 EEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAY 336
            ||||||||||||||||||||.:||||:|:||.|:.|||.||.|||.||||:||||||||||||||
Mosquito   265 EEIKKHEWFQKDLPAYLFPSPVEQDSSVVDTNAIREVCEKFSVKEHEVHNALLSGDPHDQLAIAY 329

  Fly   337 HLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTAT 401
            ||||||||.||:||..  |:..|:||||||||                         .|.|...|
Mosquito   330 HLIIDNKRIADEAAKA--ELKEFYVAGSPPPP-------------------------GADSKFGT 367

  Fly   402 P-----VPPVAGGTPSSTIPIRP---HPERIAPMRDRQLA----MSVQT----SGGGAFPEKTAR 450
            |     :.|...||||.  |.:.   |||||||:|:|.:.    |.|.|    |.....|....|
Mosquito   368 PLGPGSIAPTQAGTPSE--PFKSPSIHPERIAPLRERPVTAAQNMPVPTLSTMSPSAVMPIDKHR 430

  Fly   451 GGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQL 515
             |||:|||||||||||||||||||||||||||||.:|||||||||||||:.|.:..|..||||||
Mosquito   431 -GTPVKRAKWHLGIRSQSKPNDIMLEVYRAMKALDFEWKIINPYHVRVRKYNARNDKHVKMSLQL 494

  Fly   516 YQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGVMPL----QPTGHHTMEFFEMCAAL 576
            ||||.|:||||||||||||||||||||||||||||....|.|.:    ||:|||||||||||.||
Mosquito   495 YQVDPKNYLLDFKSLTNDEVEQGDDVIMESLTPPPPVGFGGMGIPSNHQPSGHHTMEFFEMCGAL 559

  Fly   577 IIQLAR 582
            |.||||
Mosquito   560 IAQLAR 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	239/254 (94%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	44/62 (71%)
		AMPKA_C	457..580	CDD:213378	100/126 (79%)
AMPKalpha	XP_312237.4	STKc_AMPK_alpha	18..273	CDD:270981	239/254 (94%)
		UBA_AID_AMPKalpha	290..354	CDD:270521	45/63 (71%)
		AMPKA_C	436..563	CDD:213378	100/130 (77%)