Protein Alignment AMPKalpha and Chek1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_031717.2
• Gene: Chek1 / 12649
• MGIID: 1202065
• Length: 476
• Species: Mus musculus
• Alignment Length: 556
• Identity: 139/556 - (25%)
• Similarity: 218/556 - (39%)
• Gaps: 171/556 - (30%)

  Fly    33 TLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVIST 97
            |||.|.:|:|::..::||...|||||::.:  :::|....|::||...|:..|.:::|.|.....
Mouse    14 TLGEGAYGEVQLAVNRITEEAVAVKIVDMK--RAIDCPENIKKEICINKMLSHENVVKFYGHRRE 76

  Fly    98 PSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHN 162
            ....::.:||.|||||||.|.....:.|..|:|||.|:::||.|.|...|.|||:||||||||..
Mouse    77 GHIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDER 141

  Fly   163 MHVKIADFGLSNMMLDG---EFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTL 224
            .::||:||||:.:....   ..|...||:..|.|||::..|.:....||:||||::|.|:|.|.|
Mouse   142 DNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKEFHAEPVDVWSCGIVLTAMLAGEL 206

  Fly   225 PFD------DEHVPTLFRKIKSGIFPIPEYLN--KQV----VNLVCQMLQVDPLKRANIEEIKKH 277
            |:|      .|:.....:|         .|||  |::    :.|:.::|...|..|..|.:|||.
Mouse   207 PWDQPSDSCQEYSDWKEKK---------TYLNPWKKIDSAPLALLHKILVETPSARITIPDIKKD 262

  Fly   278 EWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDN 342
            .|:.|.|                                                         |
Mouse   263 RWYNKPL---------------------------------------------------------N 270

  Fly   343 KRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPV---- 403
            :                   |:..|                  ..|.||.:.:|||.:..:
Mouse   271 R-------------------GAKRP------------------RATSGGMSESSSGFSKHIHSNL 298

  Fly   404 --PPVAGGTPSSTIPI---RPHPERIAPMRDRQLAMSVQTSG---------GGAFPEKTARG--- 451
              .||..|:...|:..   :|.|         :..:|:..:|         |.:|.:.|...
Mouse   299 DFSPVNNGSSEETVKFSSSQPEP---------RTGLSLWDTGPSNVDKLVQGISFSQPTCPEHML 354

  Fly   452 ------GTP----------IKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRR 500
                  |||          :||...........|....:.|.:   :.|.|:||......|.|..
Mouse   355 VNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETF---EKLGYQWKKSCMNQVTVST 416

  Fly   501 QNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVE 536
            .:.:..|.. ..:.|.::|.| .|:||:....|.:|
Mouse   417 TDRRNNKLI-FKINLVEMDEK-ILVDFRLSKGDGLE 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	94/261 (36%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	1/62 (2%)
		AMPKA_C	457..580	CDD:213378	18/80 (23%)
Chek1	NP_031717.2	Interaction with CLSPN. /evidence=ECO:0000250	1..265		94/261 (36%)
		STKc_Chk1	7..265	CDD:270971	94/261 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..331		18/166 (11%)
		Autoinhibitory region. /evidence=ECO:0000250	391..476		16/65 (25%)