Protein Alignment AMPKalpha and CHEK1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_011540862.1
• Gene: CHEK1 / 1111
• HGNCID: 1925
• Length: 492
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 111/440 - (25%)
• Similarity: 170/440 - (38%)
• Gaps: 117/440 - (26%)

  Fly   123 LQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDG---EFLRT 184
            :.|..|:|||.|:::||.|.|...|.|||:||||||||...::||:||||:.:....   ..|..
Human   118 MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNK 182

  Fly   185 SCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFD------DEHVPTLFRKIKSGIF 243
            .||:..|.|||::..:.:....||:||||::|.|:|.|.||:|      .|:.....:|
Human   183 MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKK------ 241

  Fly   244 PIPEYLN--KQV----VNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDT 302
               .|||  |::    :.|:.::|..:|..|..|.:|||..|:.|.|
Human   242 ---TYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPL------------------ 285

  Fly   303 YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPP 367
                    |.|.|...|.:..:|..|.   ..:.| |..|..|:  ..|..:...|...:.|.|.
Human   286 --------KKGAKRPRVTSGGVSESPS---GFSKH-IQSNLDFS--PVNSASSEENVKYSSSQPE 336

  Fly   368 PPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRDRQL 432
            |..                     |.|....:.:.:..:..|. |.:.|..|         |..|
Human   337 PRT---------------------GLSLWDTSPSYIDKLVQGI-SFSQPTCP---------DHML 370

  Fly   433 AMS--VQTSGGGAFP-----EKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMK----ALSY 486
            ..|  :.|.|....|     ::..|..|.:...|                 .|:.:|    .|.|
Human   371 LNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADK-----------------SYQCLKETCEKLGY 418

  Fly   487 EWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVE 536
            :||......|.:...:.:..|.. ..:.|.::|.| .|:||:....|.:|
Human   419 QWKKSCMNQVTISTTDRRNNKLI-FKVNLLEMDDK-ILVDFRLSKGDGLE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	62/171 (36%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/62 (19%)
		AMPKA_C	457..580	CDD:213378	17/84 (20%)
CHEK1	XP_011540862.1	Protein Kinases, catalytic domain	<114..281	CDD:473864	62/171 (36%)