Protein Alignment AMPKalpha and Prkaa2

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_835279.2
• Gene: Prkaa2 / 108079
• MGIID: 1336173
• Length: 552
• Species: Mus musculus
• Alignment Length: 589
• Identity: 355/589 - (60%)
• Similarity: 418/589 - (70%)
• Gaps: 76/589 - (12%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.||||||||||||:|..||||||||||||:||||||||:|||||||||||||
Mouse    11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:|.||:|||||||||||||.|||:::|.:|||.||||:|.||||||||:|||||
Mouse    76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDL 140

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||..|:.|||||||||||.||||||||||||||||||||||:|||||||||||||||||
Mouse   141 KPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            ||||||||||||||||||:||:.|:|.||:|||:.|..|:..||||||||||.|::|::||||::
Mouse   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||:||||.....|:||||..||.|||.||...|:||.|||.||||.||||:||||||||:|.
Mouse   271 DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRI-- 333

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPS 412
                 :|:.:.|::|.|||       ..|.||                  .:|..:||
Mouse   334 -----MNQASEFYLASSPP-------SGSFMD------------------DSAMHIPP------- 361

  Fly   413 STIPIRPHPERIAPM-RDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLE 476
               .::|||||:.|: .|...|.....:.....|:..|     :|:||||||||||||..|||.|
Mouse   362 ---GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLA-----VKKAKWHLGIRSQSKACDIMAE 418

  Fly   477 VYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQ--GD 539
            ||||||.|.:|||::|.||:||||:|..||.:.|||||||.||::||||||||:.::.|||  |.
Mouse   419 VYRAMKQLGFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDSRSYLLDFKSIDDEVVEQRSGS 483

  Fly   540 DVIMESLTPPPL---------------SVSGVMPLQPT-----------GHHTMEFFEMCAALII 578
            .....|.:...|               |:||.:....|           |.|||:||||||:||.
Mouse   484 STPQRSCSAAGLHRARSSFDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLIT 548

  Fly   579 QLAR 582
            .|||
Mouse   549 ALAR 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	208/254 (82%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	35/62 (56%)
		AMPKA_C	457..580	CDD:213378	75/150 (50%)
Prkaa2	NP_835279.2	STKc_AMPK_alpha	13..268	CDD:270981	208/254 (82%)
		UBA_AID_AAPK2	285..349	CDD:270587	40/77 (52%)
		AIS. /evidence=ECO:0000250	291..376		48/126 (38%)
		AMPKA_C_like	395..550	CDD:388390	77/159 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833060
Domainoid	1	1.000	433	1.000	Domainoid score	I572
eggNOG	1	0.900	-	-		E33208_3BB6Z
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4551
Inparanoid	1	1.050	665	1.000	Inparanoid score	I747
Isobase	1	0.950	-	0	Normalized mean entropy	S655
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm43843
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.830