Protein Alignment AMPKalpha and Prkaa1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 629
• Identity: 338/629 - (53%)
• Similarity: 408/629 - (64%)
• Gaps: 130/629 - (20%)

  Fly    23 VKIGHYLLGATLGTGTFGKVK------------------------------IGEHQITRVKVAVK 57
            ||||||:||.|||.|||||||                              :|:|::|..|||||
Mouse    22 VKIGHYILGDTLGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKVAVK 86

  Fly    58 ILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGK 122
            |||||||:||||||||||||||||||||||||||||||||||||||:|||||||||||||.|:|:
Mouse    87 ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR 151

  Fly   123 LQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCG 187
            |.|.::||.||||:||||||||||:|||||||||:|||.:|:.|||||||||||.||||||||||
Mouse   152 LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG 216

  Fly   188 SPNYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQ 252
            ||||||||||||:|||||||||||.||||||||||||||||:||||||:||..|||..|:|||..
Mouse   217 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 281

  Fly   253 VVNLVCQMLQVDPLKRANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKET 317
            |::|:..||||||:|||.|::|::||||::|||.||||......|.:||..|:.|||.||...|.
Mouse   282 VISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEE 346

  Fly   318 EVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSM-DHQ 381
            ||.:.|.:.:..|.||:||||||||:|.       :||..:|::|.||        |.|.: ||.
Mouse   347 EVLSCLYNRNHQDPLAVAYHLIIDNRRI-------MNEAKDFYLATSP--------PDSFLDDHH 396

  Fly   382 APLATVTVGGGTSASSGTATPVPPVAGGTPSSTIPIRPHPERIAPM-----RDRQLAMSVQTSGG 441
            .                                  .||||||:..:     |.|.....:.
Mouse   397 L----------------------------------TRPHPERVPFLVAETPRARHTLDELN---- 423

  Fly   442 GAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTG 506
               |:|:...|  :::|||||||||||:|||||.||.||:|.|.||||::|||::||||:|..|.
Mouse   424 ---PQKSKHQG--VRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTS 483

  Fly   507 KFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQ---------------------------------G 538
            .||||||||||||:::|||||:|: :||:.:                                 .
Mouse   484 TFSKMSLQLYQVDSRTYLLDFRSI-DDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPS 547

  Fly   539 DDVIMESLTPPPLSVSGVMPLQPTGHHTMEFFEMCAALIIQLAR 582
            |..:..|:|....|...|.| :| |.||:|||||||.||..||:
Mouse   548 DVSLTSSVTSLDSSPVDVAP-RP-GSHTIEFFEMCANLIKILAQ 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/284 (72%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	27/62 (44%)
		AMPKA_C	457..580	CDD:213378	74/155 (48%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	205/284 (72%)
		UBA_AID_AAPK1	326..390	CDD:270586	32/78 (41%)
		AMPKA1_C	434..587	CDD:213384	74/155 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	433	1.000	Domainoid score	I572
eggNOG	1	0.900	-	-		E33208_3BB6Z
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	665	1.000	Inparanoid score	I747
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275232at33208
OrthoFinder	1	1.000	-	-		FOG0000976
OrthoInspector	1	1.000	-	-		otm43843
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1362
SonicParanoid	1	1.000	-	-		X997
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.960