DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and SIK1B

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001307572.1	Gene:	SIK1B / 102724428	-ID:	-	Length:	783	Species:	Homo sapiens

Alignment Length:	451	Identity:	171/451 - (37%)
Similarity:	249/451 - (55%)	Gaps:	57/451 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLD 68
            |...:|:....|....:|| ::|.|.:..|||.|.|..||:..|::|:.:||:||:::.::.|.:
Human     4 MSEFSADPAGQGQGQQKPL-RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN 67

  Fly    69 VVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQ 133
             :.||.||:|.:||..||||||||||:.|...::::.|:...||:|||:..:|.|.|::||:.|.
Human    68 -LEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFW 131

  Fly   134 QIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVIS 198
            ||:|.|:|||.|.|||||||.||||||.||.:|:||||..|....||.|.|.||||.||||||..
Human   132 QILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFE 196

  Fly   199 GKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQV 263
            ||.|.||::||||.||:||.|:||:||||..::|||.:::..|.|.||.::::...:|:.:||.|
Human   197 GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVV 261

  Fly   264 DPLKRANIEEIKKHEWFQKD--LPAYLFP--SSIEQDSNV--IDTYAVAEVCTKFGVKETEVHNS 322
            ||.:|..|.:|::|.|.:.:  ||....|  |:....||:  .|..|:. :....||.......|
Human   262 DPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALG-IMQTLGVDRQRTVES 325

  Fly   323 LLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATV 387
             |....::..|..|:|:::          ::.|..|...|  .|.|...|.|:|
Human   326 -LQNSSYNHFAAIYYLLLE----------RLKEYRNAQCA--RPGPARQPRPRS----------- 366

  Fly   388 TVGGGTSASSGTATPVPPVAGGTPSSTIPIR-----PHPERI------APMRDRQLAMSVQ 437
                  |..||...|...:      ||.|.|     |.|:.:      |.| |.:|..|:|
Human   367 ------SDLSGLEVPQEGL------STDPFRPALLCPQPQTLVQSVLQAEM-DCELQSSLQ 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	126/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/64 (20%)
		AMPKA_C	457..580	CDD:213378
SIK1B	NP_001307572.1	STKc_SIK	26..278	CDD:270973	125/252 (50%)
		UBA_SIK1	300..349	CDD:270591	11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910