DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and LOC102551633

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_038936415.1	Gene:	LOC102551633 / 102551633	RGDID:	7576862	Length:	474	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	133/419 - (31%)
Similarity:	198/419 - (47%)	Gaps:	51/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 HYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKL 91
            ||.:.:.||.|:||.|.:..|..|:..||:|:|...|    :.:..|..|...|:...||:||:|
  Rat    13 HYKILSYLGQGSFGTVNLAWHLKTQALVAIKMLEISK----ETISSILSERAILETLHHPNIIRL 73

  Fly    92 YQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPEN 156
            :||:.|.|.:..::||..||.||:.|.:.|.|||..|::.|.|.:|.|.|||...|||||:||:|
  Rat    74 FQVLITSSHVNFVLEYAPGGSLFELIKEGGPLQEEVAKKIFGQTVSAVKYCHNLDIVHRDIKPQN 138

  Fly   157 LLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLC 221
            :|.|...:.|:.||||:.....|..|:..||:..:.|||::..:.|.|.:.|:||.||:||.:..
  Rat   139 ILTDAEGNGKLTDFGLATKFRPGTLLKELCGTKEFYAPELVLREPYNGKKTDVWSLGVLLYFIST 203

  Fly   222 GTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK---D 283
            |..||.......:.:||.:|.:.||.|.:.|:.||:.|:|.|.|..|.:||:|:||.|.:|   :
  Rat   204 GYCPFRGVTTKDMEKKIATGTYTIPTYFSGQLENLIHQILTVSPEMRPSIEDIEKHPWVRKCEVN 268

  Fly   284 LPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADD 348
            :|....|.           |.:.|:....|....::..| |....:|:...||.::.|..|
  Rat   269 IPTITCPD-----------YKIVEMLCGMGYNANKILES-LQKKKYDEPMAAYLILKDKVR---- 317

  Fly   349 AANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAP--------------LATVTVGGGTSASSGT 399
                 .||.:.......|....|..|||...|...              |..:...|...|....
  Rat   318 -----QEIEHGTTTSDMPVDQGPLPPQSPAHHSVSGLPLKRRASEPNFGLLHIWPPGEQVARHNV 377

  Fly   400 ATPV--PPVA-------GGTPSSTIPIRP 419
            |..|  ||:|       ..|.:|.:..||
  Rat   378 ARSVSMPPIALYGTKKQNSTSTSALHSRP 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	99/252 (39%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/62 (19%)
		AMPKA_C	457..580	CDD:213378
LOC102551633	XP_038936415.1	STKc_AMPK-like	13..261	CDD:270905	99/251 (39%)
LOC102551633	XP_038936415.1	UBA_MARK_Par1	275..314	CDD:270522	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010