Protein Alignment AMPKalpha and sik3

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_004916140.2
• Gene: sik3 / 100492939
• XenbaseID: XB-GENE-6042192
• Length: 1284
• Species: Xenopus tropicalis
• Alignment Length: 772
• Identity: 216/772 - (27%)
• Similarity: 325/772 - (42%)
• Gaps: 238/772 - (30%)

  Fly     1 MPQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIK 65
            :|..|||.|              :||:|.:..|:|.|.|..||:..|.:||.|||:||:::.|:.
 Frog    13 LPPHRAAPA--------------RIGYYEIDRTIGKGNFAVVKLATHIVTRAKVAIKIIDKTKLD 63

  Fly    66 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARR 130
            . :.:.||.||:|.:|:..|||||:||||:.|...|:::.||.||||:||::|.||::.|.:||:
 Frog    64 E-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARK 127

  Fly   131 FFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPE 195
            .|:||::.|.:||...|||||||.||||||.|:::||||||.||....|:.|:|.||||.|||||
 Frog   128 KFKQIVAAVHFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNRFTPGQLLKTWCGSPPYAAPE 192

  Fly   196 VISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQM 260
            :..||.|.||:|||||.||:||.|:||.||||...:..|..::.||.|.||.:::.:..:|:..|
 Frog   193 LFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHM 257

  Fly   261 LQVDPLKRANIEEIKKHEWF---QKDLP-----AYLFPSSIEQDSNVIDTYAVAEVCTKFGVKET 317
            |.::|.||.::|:|.||:|.   ::||.     |......:|:..:.::...:..: .:.|:...
 Frog   258 LVLEPSKRLSMEQICKHKWMCQGEQDLEFERLIAECQHVKLERQRDPLNEQVLLTM-VEMGLDRE 321

  Fly   318 EVHNSLLSGDPHDQLAIAYHLIIDN-KRF-----------------------ADDAA-------- 350
            ....||.: |.:|..:..|.|:.|. ||.                       ||.|:
 Frog   322 RTLQSLRT-DAYDHYSAIYSLLCDRLKRHKTLRLPTQPSAPRTVSYSTPSVQADAASNTVSINVP 385

  Fly   351 --------NQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVG-GGTSASSGTATPVPPV 406
                    |||.|.|......|.....|.|   .::.....:...||| ..|...||| ..:..:
 Frog   386 QVQLINPENQIVETNGTMTLDSDEAEEPSP---EALARYLSMRRHTVGVPDTHNESGT-DELQKI 446

  Fly   407 AGGTPSST--IPIRPHPER------IAPM--------RDRQL-------------AMSVQTSGGG 442
            ..|.|..|  ||..|..:.      :.||        :::.|             .:..:.|.||
 Frog   447 FPGFPRVTQQIPFLPVTQNTNVLHTLLPMPPSAHLEYKEQSLLQPPTLQLLNGMGPLGRRASDGG 511

  Fly   443 AFPE-------KTARGGTPI--------------------------------KRAKWH------- 461
            |..:       |..||.:|:                                .|.|.|
 Frog   512 ANIQMHAQLLLKRPRGPSPLVTMATTVTAVTPVDEESSDGEPDQEAVQRYLANRTKRHTLAMTSP 576

  Fly   462 -----------LG----IRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRR----------- 500
                       ||    .|:::.|..:..:::|:|      :|..|..|:...|
 Frog   577 TAEIPPELQRQLGQQQAFRNRAWPPHLAPDLHRSM------YKDSNTLHLPAERFSPVRRFSDGA 635

  Fly   501 ---------------QN----------------------VKTGKFSKMSLQLYQVDAKSYLLDFK 528
                           ||                      .:|.:.::....:||.:.:.:||.
 Frog   636 ATIQAFKAHLEKMGNQNSSIKQLQQECEQLQKMYGVHMDERTLEHTQQQHVMYQHEHQHHLLQ-- 698

  Fly   529 SLTNDEVEQGDDVIMESLTPPPLSVSGVMPL---QPTGHHTMEFFEMCAALIIQLAR 582
                   :|..|.|..:...|||..|.:.|.   ||            |.|..||.|
 Frog   699 -------QQIQDCIRPAQPSPPLQSSSMTPASENQP------------ALLTHQLQR 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	126/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	18/102 (18%)
		AMPKA_C	457..580	CDD:213378	32/195 (16%)
sik3	XP_004916140.2	STKc_SIK	25..277	CDD:270973	124/252 (49%)
		UBA_SIK3	306..350	CDD:270593	10/45 (22%)