Protein Alignment AMPKalpha and mark4

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_012824414.1
• Gene: mark4 / 100491038
• XenbaseID: XB-GENE-6042140
• Length: 681
• Species: Xenopus tropicalis
• Alignment Length: 648
• Identity: 194/648 - (29%)
• Similarity: 284/648 - (43%)
• Gaps: 157/648 - (24%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKI--KSLDVVGKIRREIQNLKLFRHPH 87
            :|:|.|..|:|.|.|.|||:..|.:|..:||:||:::.::  .||.   |:.||::.:|...||:
 Frog    48 VGNYRLLRTIGKGNFAKVKLARHVLTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMKGLNHPN 109

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |:||::||.|...:::||||.||||:|||:|.||:::|.:||..|:||:|.|.|||:..||||||
 Frog   110 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDL 174

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            |.||||||...::||||||.||....|..|.|.||||.|||||:..||.|.|||||:||.|||||
 Frog   175 KAENLLLDSESNIKIADFGFSNEFTPGGKLDTFCGSPPYAAPELFQGKRYNGPEVDVWSLGVILY 239

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF-- 280
            .|:.|:||||.:::..|..::..|.:.||.|::.....::.:.|.::|.||..:::|...:|.
 Frog   240 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNI 304

  Fly   281 ---QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLI--- 339
               ..||..|..|.....|...|      |:..:.|....|:.:: ||.:.::::...|.|:
 Frog   305 GFDSDDLKPYKEPEEDNADPKRI------EIMLEMGYSREEIKDA-LSSNKYNEVMATYLLLGRK 362

  Fly   340 ---------------IDNKRFADDAAN----------------QINEINNFFVAGSPPP------ 367
                           :...|.|.|..|                |....::.|...:|.|
 Frog   363 PESEGGESRSDSTLSLSRSRVASDVTNGATKSSSVHSKNQRGYQRQRRHSDFCGPAPAPSQAKRS 427

  Fly   368 ----------------------------PPPPPVPQSSMDH------------QAPLATVTVGGG 392
                                        ||||..|..|..|            :||..|:.
 Frog   428 PPGVGDDGAVGERLAPRRGSGSVGGGSRPPPPSSPMVSHAHNPNKAEIPEPRKEAPPTTIN---- 488

  Fly   393 TSASSGTATPVPPVAGGTPSSTIPIRPHPER-----------IAPMRDRQLAMSVQTSGGGAFPE 446
                    || |.|.|...:.....|...||           ..|.|...|:.|.|:.   |...
 Frog   489 --------TP-PGVMGRRNTYVCTDRHSSERHSLLHNDKENSSTPSRPPALSPSTQSI---AERS 541

  Fly   447 KTARGGTPIKRAKWHLG----IRSQSKPNDIMLEVYRAMKALSYEWKIINPYH----VRVRRQNV 503
            ..:||..  .|:.:|.|    .|.|:.|..                   :|.|    :...|...
 Frog   542 SLSRGSN--VRSTFHGGHVRDRRGQNPPPS-------------------SPTHPHEGLNQSRTRA 585

  Fly   504 KTGKFSKMSLQL-YQVDAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSV---SGVMPLQPT 562
            .:..|||::.:| .:|..:|..:....:|...:.........||..||..|   |...|||||
 Frog   586 TSNLFSKLTSKLTRRVTDESERVWRPEVTGSYIPWNKTSANSSLLRPPRDVRRSSQHPPLQPT 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	119/256 (46%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	13/96 (14%)
		AMPKA_C	457..580	CDD:213378	27/118 (23%)
mark4	XP_012824414.1	STKc_MARK	50..302	CDD:270974	118/254 (46%)
		UBA_MARK_Par1	323..361	CDD:270522	9/44 (20%)