Protein Alignment AMPKalpha and mark1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_002936069.2
• Gene: mark1 / 100490022
• XenbaseID: XB-GENE-962867
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 651
• Identity: 189/651 - (29%)
• Similarity: 307/651 - (47%)
• Gaps: 150/651 - (23%)

  Fly     1 MPQMRAAAAEAV------AAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKIL 59
            :|..::::.:::      .|.:.:.||  .||:|.|..|:|.|.|.|||:..|.:|..:|||||:
 Frog    29 VPPTKSSSRQSLPRCRNSIASTTDEQP--HIGNYRLLKTIGKGNFAKVKLARHVLTGREVAVKII 91

  Fly    60 NRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQ 124
            ::.::.... :.|:.||::.:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::
 Frog    92 DKTQLNPTS-LQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMK 155

  Fly   125 EHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSP 189
            |.:||..|:||:|.|.|||:..|||||||.||||||.:|::||||||.||....|..|.|.||||
 Frog   156 EKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSP 220

  Fly   190 NYAAPEVISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVV 254
            .|||||:..||.|.|||||:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....
 Frog   221 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCE 285

  Fly   255 NLVCQMLQVDPLKRANIEEIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGV 314
            ||:.::|.::|:||.::|:|.|..|.     .::|..|..|   |.|.|  ||..: ::....|.
 Frog   286 NLLKKLLVLNPVKRGSLEQIMKDRWMNVGYEDEELKPYTEP---EPDFN--DTKRI-DIMVTMGF 344

  Fly   315 KETEVHNSLLSGDPHDQLAIAYHLIIDNKRFADDAANQI------------NEINNFFVAGSPPP 367
            ...|::|:::: ..:|:: :|.:|::..|....:....:            :::||    .|.|.
 Frog   345 SREEINNAVVN-QKYDEV-MATYLLLGRKPPEFEGTESLSSSNLCPRSRPSSDLNN----SSVPS 403

  Fly   368 PPPPPVPQS---------SMDHQAPLATVTV-----GGGTS------------------------ 394
            |....|.:|         ..||..|....:|     |...|
 Frog   404 PAHMKVQRSISANQKQRRFSDHAGPSIPPSVSYTKRGQANSVESEQKEDWDKNGSRKLSSTMVNS 468

  Fly   395 ----------------ASSGTATPVPPVAGGTPSSTIPIRPHPERIAPMRD------RQLAMSVQ 437
                            :|:||:..:.|.:|.|..:|.......:|:..:::      .:::....
 Frog   469 KGEVVASPLAGPERKKSSAGTSNSLFPGSGMTRRNTYVCERTTDRLTAVQNGKDSSLTEMSAGST 533

  Fly   438 TSGGGAFPEKTAR-------GGTPIK--------------------------------------R 457
            ||...|.|....|       .|.|||                                      |
 Frog   534 TSTASAVPSARPRHQKSMSASGHPIKVTLPTIKDGTEGFRPSTGTQRVPATSPSAHSISATTPDR 598

  Fly   458 AKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVR----RQNVKTGKFSKMSLQLYQV 518
            .::..|..|:|..:.   |..|..:..:|.....:|.|...:    |:...||..||::.:..:.
 Frog   599 TRFPRGSTSRSTFHG---EQLRDRRTATYNGPPASPAHETTQFSHSRRGTSTGIISKITSKFARR 660

  Fly   519 D 519
            |
 Frog   661 D 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	124/254 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/74 (16%)
		AMPKA_C	457..580	CDD:213378	15/67 (22%)
mark1	XP_002936069.2	STKc_MARK	59..311	CDD:270974	122/252 (48%)
		UBA_MARK1	331..371	CDD:270588	9/44 (20%)
		MARK1-3_C	693..790	CDD:213381

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910