Protein Alignment AMPKalpha and brsk2a

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_017209738.1
• Gene: brsk2a / 100334759
• ZFINID: ZDB-GENE-100422-2
• Length: 896
• Species: Danio rerio
• Alignment Length: 637
• Identity: 201/637 - (31%)
• Similarity: 305/637 - (47%)
• Gaps: 158/637 - (24%)

  Fly    25 IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHII 89
            :|.|.|..|||.|..|.||:|.|.:|..|||:||:||:|: |..|:.|:.|||..|||..|||::
Zfish    17 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPHVL 80

  Fly    90 KLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKP 154
            ||:.|......:::::|:|||||||||:||.|:|...:||:||:||||.:|:||.|.|.||||||
Zfish    81 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKP 145

  Fly   155 ENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
            ||||||...:::|||||::::.:....|.||||||:||.||||.|:.|.|.:.|:|||||||:||
Zfish   146 ENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL 210

  Fly   220 LCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWF---- 280
            |.|.|||||:::..|..|:|.|:|.:|.::..:..||:..|::||..||..:|.|:||.|:
Zfish   211 LVGALPFDDDNLRNLLEKVKLGVFHMPHFIPPECQNLLRGMIEVDSGKRLTLELIQKHMWYIGGK 275

  Fly   281 -----QKDLPAYL----FPSSIEQDSNVIDT-YAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIA 335
                 ::.:|..:    .|||.:.|.:|::: :::.  |.:   .:.::...|||.|.:.:..|
Zfish   276 NEPEPEQPVPRKVAIRSVPSSEDIDPDVLESMHSLG--CFR---DKNKLMKDLLSDDENQEKMI- 334

  Fly   336 YHLIIDNK-RFADDAANQI---NEINNFFVAGSPPPPPPPPVPQSSMDHQA---------PLATV 387
            |.|::|.| |:.......:   |:|:          ||...|....::...         .:.:|
Zfish   335 YFLLLDRKERYPSQEDQNLPPRNDID----------PPRKRVDSPMLNRHGKRRPERKSMEVLSV 389

  Fly   388 TVGGG-------------------------------------------TSASSGTATP------- 402
            |.||.                                           :.||||.:|.
Zfish   390 TDGGSPVPARRAIDMTQHGQSKSTFSKSLDISDAKHKAKSKEERSRSISGASSGLSTSPLSSPRP 454

  Fly   403 -----VPPVAGG---TPSSTIPIRPHPERIAPMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAK 459
                 |||.:..   :|||:|     .:.:.|..|:.:|             ||:...||...::
Zfish   455 VRKFCVPPQSSELLLSPSSSI-----IDSLKPNSDQNMA-------------KTSNSLTPNSISE 501

  Fly   460 WHLGI-RSQ---SKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDA 520
            ..|.. ::|   :||.|..|:..|:......|     |.|:...:....|.         .|..|
Zfish   502 SLLPYPKTQTLPAKPKDKPLQSARSNPLPESE-----PEHISTAKSEPSTP---------CQPQA 552

  Fly   521 KSYLLDFKSLTNDEVEQGDDVIME----SLTPPPLSV--SGVMPLQPTG-HH 565
            ...             .|..::..    |:.||.|||  ...:||.|.. ||
Zfish   553 PCI-------------PGSPLVRRATPASIIPPQLSVPFRPAVPLSPIRLHH 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	130/254 (51%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	14/67 (21%)
		AMPKA_C	457..580	CDD:213378	25/120 (21%)
brsk2a	XP_017209738.1	STKc_BRSK1_2	18..271	CDD:270983	130/253 (51%)
		UBA_BRSK	298..351	CDD:270525	13/58 (22%)