Protein Alignment AMPKalpha and prkaa2

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001135554.1
• Gene: prkaa2 / 100216099
• XenbaseID: XB-GENE-5994580
• Length: 551
• Species: Xenopus tropicalis
• Alignment Length: 596
• Identity: 359/596 - (60%)
• Similarity: 419/596 - (70%)
• Gaps: 91/596 - (15%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.|||||||:||||:|..||||||||||||::|||||||:|||||||||||||
 Frog    11 VKIGHYILGDTLGVGTFGKVKMGEHQLTGHKVAVKILNRQKIRNLDVVGKIKREIQNLKLFRHPH 75

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:|.||:|||||||||||||.|||:::|.:|||.||||||.||||||||:|||||
 Frog    76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEAEARRLFQQIISAVDYCHRHMVVHRDL 140

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.:|:.|||||||||||.||||||||||||||||||||||:|||||||||||||||||
 Frog   141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            ||||||||||||||||||:||:.|:|.||||||:....|:..||||||||||.|::|::||||::
 Frog   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSAATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||:||||.....|:||||..||.|||.||...|:||.|||.||||.||||:||||||||:|.
 Frog   271 DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRI-- 333

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPS 412
                 :|:.:.|::|.|||.                        |:.....| ..:||
 Frog   334 -----MNQASEFYLASSPPT------------------------GSFIDEST-LHIPP------- 361

  Fly   413 STIPIRPHPERIAPM-RDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPNDIMLE 476
               .::|||||:.|: .|...|.....:.....|:..|     :|:|||||||||||||.|||.|
 Frog   362 ---GVKPHPERMPPLIADSPKARCPLDALNTTKPKPLA-----VKKAKWHLGIRSQSKPYDIMAE 418

  Fly   477 VYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVEQGDDV 541
            ||||||.|.:|||::||||:||||:|..||.:.||||||||||.:||||||||:        ||.
 Frog   419 VYRAMKQLDFEWKVVNPYHLRVRRKNPVTGTYVKMSLQLYQVDNRSYLLDFKSI--------DDE 475

  Fly   542 IME----SLTP-----------PPLSV------------------SGVMPL-QP-TGHHTMEFFE 571
            :||    |.||           |.||:                  ||...| .| .|.|||:|||
 Frog   476 VMEQKSGSSTPQRSCSAAGLHRPRLSIDSSTSDYSAPSGPLFGSFSGSFSLVNPRLGSHTMDFFE 540

  Fly   572 MCAALIIQLAR 582
            |||:||..|||
 Frog   541 MCASLITTLAR 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	207/254 (81%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	35/62 (56%)
		AMPKA_C	457..580	CDD:213378	82/157 (52%)
prkaa2	NP_001135554.1	STKc_AMPK_alpha	13..268	CDD:270981	207/254 (81%)
		UBA_AID_AAPK2	285..349	CDD:270587	40/94 (43%)
		AMPKA2_C	395..549	CDD:213385	84/166 (51%)