Protein Alignment AMPKalpha and prkaa1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001120434.1
• Gene: prkaa1 / 100145520
• XenbaseID: XB-GENE-946195
• Length: 551
• Species: Xenopus tropicalis
• Alignment Length: 600
• Identity: 347/600 - (57%)
• Similarity: 410/600 - (68%)
• Gaps: 101/600 - (16%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.|||||||:|:|::|..||||||||||||:||||||||||||||||||||||
 Frog    13 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 77

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:||||:|||||||||||||.|:|||.|.::||.||||:||||||||||:|||||
 Frog    78 IIKLYQVISTPTDIFMVMEYVSGGELFDYICKNGKLDEKESRRLFQQILSGVDYCHRHMVVHRDL 142

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.:|:.|||||||||||.||||||||||||||||||||||:|||||||||||||||||
 Frog   143 KPENVLLDAHMNAKIADFGLSNMMADGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 207

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            |||||||||||:||||||:||..|||..|:|||..|::|:..||.|||:|||.|::|::||||:.
 Frog   208 ALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPPVISLLKHMLLVDPMKRATIKDIREHEWFKL 272

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||.||||......||:||..|:.|||.|....|.||.:.|.|.:..|.||:||||||||:|.
 Frog   273 DLPKYLFPEDPSYSSNMIDDEALKEVCEKCECLEEEVLSCLYSRNHQDPLAVAYHLIIDNRRI-- 335

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMDHQAPLATVTVGGGTSASSGTATPVPPVAGGTPS 412
                 :||..:|::|.||        |.|.|:.                       |.||
 Frog   336 -----MNEAKDFYLATSP--------PDSFMEE-----------------------PQVA----- 359

  Fly   413 STIPIRPHPERI------APMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRSQSKPN 471
                 ||||||:      :| |.|.....:.       |:|| :....::||||||||||||:||
 Frog   360 -----RPHPERVPFLVAESP-RQRHTLDELN-------PQKT-KHQVGVRRAKWHLGIRSQSRPN 410

  Fly   472 DIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTNDEVE 536
            |||.||.||||.|.||||::|||::||||:|..|..::||||||||||:::|||||:|: :|||.
 Frog   411 DIMAEVCRAMKQLGYEWKVVNPYYLRVRRKNPVTSMYTKMSLQLYQVDSRTYLLDFRSI-DDEVT 474

  Fly   537 QGDDVIMESLTP----------PP----------LSVSGVMPLQPT--------------GHHTM 567
            :...   ||.||          ||          .|..|..|...|              |.||:
 Frog   475 EAKS---ESATPRRSGSISNYRPPKNDSDPEIQAKSSDGSGPSSLTSSVDSSNADLVPRPGSHTI 536

  Fly   568 EFFEMCAALIIQLAR 582
            |||||||.||..|||
 Frog   537 EFFEMCANLIKILAR 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/254 (81%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	28/62 (45%)
		AMPKA_C	457..580	CDD:213378	78/156 (50%)
prkaa1	NP_001120434.1	STKc_AMPK_alpha	15..270	CDD:270981	205/254 (81%)
		UBA_AID_AAPK1	287..351	CDD:270586	33/78 (42%)
		AMPKA1_C	396..549	CDD:213384	78/156 (50%)