DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AMPKalpha and mark2b

DIOPT Version :9

Sequence 1:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_009301419.1	Gene:	mark2b / 100005996	ZFINID:	ZDB-GENE-080215-4	Length:	790	Species:	Danio rerio

Alignment Length:	531	Identity:	184/531 - (34%)
Similarity:	275/531 - (51%)	Gaps:	80/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKS 66
            |:.|.|.|.|        :....||:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.|
Zfish    31 PRCRNAVATA--------EEYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLNS 87

  Fly    67 LDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRF 131
             ..:.|:.||::.:||..||:|:||::||.|...::::|||.||||:|||:|.||:::|.:||..
Zfish    88 -SSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAK 151

  Fly   132 FQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEV 196
            |:||:|.|.|||:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||:
Zfish   152 FRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 216

  Fly   197 ISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQML 261
            ..||.|.|||||:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.:.|
Zfish   217 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFL 281

  Fly   262 QVDPLKRANIE-EIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVH 320
            .::|.||.::| :|.|..|.     ..||..|:.|....:|....|      :..:.|..:.|:.
Zfish   282 ILNPTKRGSLEQQIMKDRWMNVGYEDDDLKPYIEPQPDYKDPRRTD------IMLQMGFSQEEIE 340

  Fly   321 NSLLSGDPHDQLAIAYHLIIDNKRFADDAANQINEINNFFVAGSP--------PPPPPPPVPQSS 377
            :||:....::  .:|.:|::|.:.      ::::|..|..:...|        .|.||..|.:|.
Zfish   341 DSLVKQKYNE--VMATYLLLDYRN------SELDEGVNLSLKSRPGSDLTNSNAPSPPHKVQRSV 397

  Fly   378 MDHQAPLATVTVGGGTS------------------ASSGTATPVPPV------AGGTPS--STIP 416
            ...|.|....|..|..|                  :||.|..|..||      ...|||  |.:.
Zfish   398 SSTQKPARRSTDQGSYSKRPQGENKHGVEDSGRKGSSSSTKVPPSPVISSERKKSSTPSTNSILS 462

  Fly   417 IRPHPERIAPMRDR-QLAM-----SVQTSGGGAFPEKTARGGTPI-------KRAKWHLGIRSQS 468
            ......|.:|:.:| .|.:     |:.|.|..|   .||..| |:       .|.:.|..:.:.:
Zfish   463 TGTSRSRNSPISERATLGVQNGKDSLSTPGSRA---STASAG-PVLSSSSSSSRTRHHKSLSTSA 523

  Fly   469 KPNDIMLEVYR 479
            .|:...|..:|
Zfish   524 HPSPADLHSHR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	125/255 (49%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	10/62 (16%)
		AMPKA_C	457..580	CDD:213378	5/23 (22%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	123/253 (49%)
		S_TKc	49..301	CDD:214567	123/252 (49%)
		UBA_MARK2	319..360	CDD:270589	8/48 (17%)
		AMPKA_C_like	691..789	CDD:302605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910