Protein Alignment AMPKalpha and mark1

DIOPT Version :9

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001107948.1
• Gene: mark1 / 100003170
• ZFINID: ZDB-GENE-070626-2
• Length: 772
• Species: Danio rerio
• Alignment Length: 761
• Identity: 215/761 - (28%)
• Similarity: 326/761 - (42%)
• Gaps: 258/761 - (33%)

  Fly     1 MPQMRAAAAEAVAAGSANGQPLVKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIK 65
            :|:.|.:.|..     .:.||  .:|:|.|..|:|.|.|.|||:..|.:|..:|||||:::.::.
Zfish    40 LPRSRNSVASI-----TDEQP--HVGNYRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN 97

  Fly    66 SLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARR 130
            ... :.|:.||::.:|:..||:|:||::||.|...:::||||.||||:|||:|.||:::|.:||.
Zfish    98 PTS-LQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARA 161

  Fly   131 FFQQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPE 195
            .|:||:|.|.|||:..|||||||.||||||.:|::||||||.||....|..|.|.||||.|||||
Zfish   162 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYAAPE 226

  Fly   196 VISGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQM 260
            :..||.|.|||||:||.|||||.|:.|:||||.:::..|..::..|.:.||.|::....||:.::
Zfish   227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKL 291

  Fly   261 LQVDPLKRANIEEIKKHEWF-----QKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVH 320
            |.::|.||.::|:|.|..|.     :::|..|..|   |.|.:  ||..: |:....|..:.|:.
Zfish   292 LVLNPGKRGSLEQIMKDHWINVGHEEEELKPYTEP---EPDFS--DTKRI-ELMITMGFPKDEIT 350

  Fly   321 NSLLSGDPHDQLAIAYHLIIDNK--RF-ADDAANQIN---------EINNFFVAGSPPP------ 367
            .:|: |..:|:: :|.:|::..|  .| ..|:.:..|         ::||   :.|..|
Zfish   351 EALV-GQKYDEV-MATYLLLGRKPPEFEGSDSLSTTNLCQRSRPSSDLNN---SSSQSPAHSKVQ 410

  Fly   368 -----------------PPPPP--------------------------VPQSSMDHQ---APLA- 385
                             |..||                          :|.||....   :|||
Zfish   411 RSISATQKQRRFSDHVAPSIPPAVSYTKRSQANSVEGEKKEEWDASRKLPSSSSKGDMAASPLAA 475

  Fly   386 ------------------------------------------------------TVTVGGGTSAS 396
                                                                  |.:|..|.||.
Zfish   476 QERRKSSTASGNSAAGGMTRRNTYVCERSSTDRYSAIPNGKDSSLTEMSTSGSGTSSVSPGASAL 540

  Fly   397 SGT---------------ATPVPPV--------AGGTPSSTIPIRPH------PERI-------- 424
            |.|               .:|:||:        :|....||.| ..|      |:|.
Zfish   541 SSTRPRHVKSMSASGHPNKSPLPPIEDNTEFKGSGSRAPSTSP-SAHSISSMTPDRTRFPRGTSS 604

  Fly   425 ------APMRDRQ-------------------LAMS----------------VQTSGGGAFPEKT 448
                  |.:|||:                   ||.:                |:.||.|. |::.
Zfish   605 RSTFHGAQLRDRRSATYNGPPASPTLSHDTGALAQARRGTSSGFISKLTSKFVRRSGSGE-PKED 668

  Fly   449 ARGGTPIK-RAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMS 512
            .|...|.. |..|.:...|..:|.|:|.|:.:.:.|.:.:      |..|.|
Zfish   669 GRDSKPRSLRFTWSMKTTSSLEPGDMMREIRKVLDANNCD------YEQRER------------- 714

  Fly   513 LQLYQV--DAKSYLLDFKSLTNDEVEQGDDVIMESLTPPPLSVSGV 556
            ..|:.|  ||:          :|.:.|.:   ||....|.||::||
Zfish   715 FLLFCVHGDAR----------HDSLVQWE---MEVCKLPRLSLNGV 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	123/254 (48%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	16/74 (22%)
		AMPKA_C	457..580	CDD:213378	24/102 (24%)
mark1	NP_001107948.1	STKc_MARK	59..311	CDD:270974	122/252 (48%)
		S_TKc	60..311	CDD:214567	122/251 (49%)
		UBA_MARK1	331..371	CDD:270588	10/44 (23%)
		MARK1-3_C	673..770	CDD:213381	25/107 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910