Protein Alignment AMPKalpha and prkaa1

DIOPT Version :10

• Sequence 1: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001103756.1
• Gene: prkaa1 / 100001198
• ZFINID: ZDB-GENE-030325-1
• Length: 573
• Species: Danio rerio
• Alignment Length: 621
• Identity: 344/621 - (55%)
• Similarity: 410/621 - (66%)
• Gaps: 120/621 - (19%)

  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87
            ||||||:||.|||.|||||||:|:|::|:.:|||||||||||:||||||||||||||||||||||
Zfish    12 VKIGHYILGDTLGVGTFGKVKVGQHELTKHQVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 76

  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDL 152
            |||||||||||:||||:|||||||||||||.|:|||.|.::||.|||||||||||||||:|||||
Zfish    77 IIKLYQVISTPTDIFMVMEYVSGGELFDYICKNGKLDEKESRRLFQQIISGVDYCHRHMVVHRDL 141

  Fly   153 KPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILY 217
            ||||:|||.:|:.|||||||||||.||||||||||||||||||||||:|||||||||||.|||||
Zfish   142 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILY 206

  Fly   218 ALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHEWFQK 282
            |||||||||||:||||||:||..|||..|:|||..|::|:..||||||:|||.|:||::.|||::
Zfish   207 ALLCGTLPFDDDHVPTLFKKICDGIFFTPQYLNPSVISLLKHMLQVDPMKRATIKEIREDEWFKQ 271

  Fly   283 DLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQLAIAYHLIIDNKRFAD 347
            |||.||||......||:||..|:.|||.|....|.||.|.|.|.:..|.||:||||||||:|.
Zfish   272 DLPKYLFPEDAAYSSNMIDEEALKEVCEKCECTEEEVLNCLYSRNHQDPLAVAYHLIIDNRRI-- 334

  Fly   348 DAANQINEINNFFVAGSPPPPPPPPVPQSSMD-----HQAPLATVTVGGGTSASSGTATPVPPVA 407
                 ::|..:|::|.||        |.|.:|     |.|
Zfish   335 -----MSEAKDFYLASSP--------PDSFLDDLPAHHSA------------------------- 361

  Fly   408 GGTPSSTIPIRPHPERI------APMRDRQLAMSVQTSGGGAFPEKTARGGTPIKRAKWHLGIRS 466
                      :.||||:      :..|.|.....:.       |:|:...|  ::||||||||||
Zfish   362 ----------KVHPERVPFLVAESQPRPRHTLDELN-------PQKSKHLG--VRRAKWHLGIRS 407

  Fly   467 QSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLT 531
            ||:|||||.||.||||.|.||||::|||::||||:|..||..:||||||||||:::|||||:|:.
Zfish   408 QSRPNDIMSEVCRAMKQLDYEWKVVNPYYLRVRRKNPVTGMHTKMSLQLYQVDSRTYLLDFRSID 472

  Fly   532 ND--EVEQG----------------------------DDVIMESLTP--PPLSVSGVMP------ 558
            :|  ||:.|                            |....|:..|  ||:|.|.|..
Zfish   473 DDMMEVKSGTATPHRSGSVGNYRTTLKNDKSEKNECEDAAKGEASAPSTPPISASKVAEGSLASS 537

  Fly   559 ------------LQPTGHHTMEFFEMCAALIIQLAR 582
                        |...|.||:|||||||.||..|||
Zfish   538 LTSSVDSTGGEILPRPGSHTIEFFEMCANLIKLLAR 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/254 (81%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	28/62 (45%)
		AMPKA_C	457..580	CDD:213378	79/172 (46%)
prkaa1	NP_001103756.1	STKc_AMPK_alpha	14..269	CDD:270981	205/254 (81%)
		UBA_AID_AAPK1	286..350	CDD:270586	33/78 (42%)
		AMPKA1_C	398..571	CDD:213384	79/172 (46%)