Protein Alignment chb and STU1

DIOPT Version :9

• Sequence 1: NP_524651.2
• Gene: chb / 43901
• FlyBaseID: FBgn0021760
• Length: 1491
• Species: Drosophila melanogaster
• Sequence 2: NP_009519.1
• Gene: STU1 / 852246
• SGDID: S000000130
• Length: 1513
• Species: Saccharomyces cerevisiae
• Alignment Length: 1554
• Identity: 271/1554 - (17%)
• Similarity: 494/1554 - (31%)
• Gaps: 570/1554 - (36%)

  Fly    61 SHFKIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLP- 124
            :|.::.:..:.:|:.|   |.::.|       .|..|   |:.:.:.|    |:.|:| ::.|.
Yeast   188 NHLQLLRFFMLSFTNL---LNNNLN-------EHAND---DNNNVIIE----LIFDIM-YKYLKM 234

  Fly   125 ----PQALIDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVR 185
                .|.|||......   :..|.:::|: ::..:..::|:|:              ...|:...
Yeast   235 DDENSQDLIDGFINDL---EVEKFKQKFI-SLAKSQDQHGSQE--------------DKSTLFDE 281

  Fly   186 EAAIQTLVEIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQ-----EGLLLP-SALKNTNG 244
            |...|.|:...|         |.::.:..:||...:::.::.:.|     |.||.| .::|.|..
Yeast   282 EYEFQLLLAEAK---------LPQLSNNLSSKDPAMKKNYESLNQLQQDLENLLAPFQSVKETEQ 337

  Fly   245 NGVGLDEADNIGLRERPTRMIKRPLHSAVSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQLN 309
            |           .:.|.:.:|:  |.:.:|.:: ||.|            .|.|.:..:.|
Yeast   338 N-----------WKLRQSNIIE--LDNIISGNI-PKDN------------PEEFVTVIKEV---- 372

  Fly   310 IFHAKDMDDIYKQVLVIISDKNADWEKRVDALK---KIRALLILSYHTQPQFVAVQLKELSLSFV 371
                        |::.:||       :...:|:   .:.|||.|.     :.:.:...:|.||.:
Yeast   373 ------------QLIELIS-------RATSSLRTTLSLTALLFLK-----RLIHILNDQLPLSIL 413

  Fly   372 D----ILK------EELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASA 426
            |    |.|      :::.||......||:........|||  |..|.|     ||..........
Yeast   414 DQIFVIFKNLLSSTKKISSQTAFHCLITLIIDINHFHNKL--FQLSFL-----LINEKTVTPRFC 471

  Fly   427 STIALK-YIIKYTHAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTL 490
            |.|.|: ::||:..:       ..:||.|.:....|.| |..::..|||               |
Yeast   472 SAILLRSFLIKFNDS-------NLSLNNSNTTSPTSKL-ENNIIYIEEW---------------L 513

  Fly   491 KKSIGDADCDARRHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAP 555
            ||.|.|:....|...|..:|.|.:.:|..|.::                         ..:..:|
Yeast   514 KKGISDSQTTVREAMRLTFWYFYKCYPTNAKRL-------------------------LSSSFSP 553

  Fly   556 ETRRTVSRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTG 620
            :.::.                         |..|..|.:...|                |.|...
Yeast   554 QLKKA-------------------------TELAIPAHLNINY----------------QVSRVS 577

  Fly   621 AAASGSLPRPRLNSNSGGTPATTPGSVTPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGNYYR 685
            :.||.|....||.|:|                           |.::|..|.|.:|.....:|
Yeast   578 STASASSATSRLYSHS---------------------------SNNSSRKTSLLEQKRNYPSY-- 613

  Fly   686 GATGAIPKKASGIPRSTASSRETSPTRSGGG--------------LMKRSMYSTGAGSRR----- 731
                |.|      .:|:::|...:|..:.||              |...|.||:....:|
Yeast   614 ----AQP------TQSSSTSLLNAPAVTAGGSVIASKLSNKLKTNLRSTSEYSSKENEKRARHHD 668

  Fly   732 ---------TPERNNPV--RPSAAARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRKL 785
                     |.:.||..  :.||.....|.::.:|           :|.:.|...|..:
Yeast   669 SMNSVSNSNTKDNNNVTKRKVSAPPSSTAATKVSE-----------NYTNFDDFPSNQI------ 716

  Fly   786 MGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCAST 850
               |.:|::.:..|:...::..|.:....:.|..||.||:...::.|....|:|.....|.
Yeast   717 ---DLTDELSNSYSNPLIKKYMDKNDVSMSSSPISLKGSNKLGEYETLYKKFNDASFPAQI---- 774

  Fly   851 HWSERKDGLISLTQYLADGKELTQQQ--------LKCVLDMFR----------KMFMDTHTKVYS 897
                 ||.|    |||.....||.||        ...::...|          |.|:........
Yeast   775 -----KDAL----QYLQKELLLTSQQSSSAPKFEFPMIMKKLRQIMIKSPNDFKPFLSIEKFTNG 830

  Fly   898 LFLDTVTELILVHANELHEW---------------LFILLTRLFNKLGTDLLNS---MHSKIWKT 944
            :.|:.:.||..:::.:..|.               |.|.:..|||.|..:...:   ::...:||
Yeast   831 VPLNYLIELYSINSFDYAEILKNRMNPEKPYELTNLIITIADLFNFLNANNCPNDFKLYYMKYKT 895

  Fly   945 LQVVHEYFPTQLQ-LKELFR---IISDSTQTPTTK---TRIAILRFLTDLANTYCKSSDFPSDQS 1002
                 .:|....: |.|:||   |..|:|....|.   .:|:::.|     ..|.|..|:
Yeast   896 -----TFFNYNFKLLLEIFRNLNIKHDNTLRSGTNDLMPKISMILF-----QIYGKEFDY----- 945

  Fly  1003 QACERTVLKLAQLAADQKSMELRSQARSC----LVALYNLNTPQMTLLLADLPKVYQDSARSCIH 1063
                                       :|    :..:|..:..:...||||. .:.....:.| |
Yeast   946 ---------------------------TCYFNLIFEIYKFDNNRFNKLLADF-DIVSTKMKIC-H 981

  Fly  1064 SHMRRQS----QSCNSGANSPSSSPLSSSS----------------PKPLQSPSVGPFASLQSHH 1108
            ...::.:    :...|..:|.|.:|:.:..                .|.::...:.||.:|::
Yeast   982 ELEKKDANFKVEDIISRESSVSFTPIDNKKSEGDEESDDAVDENDVKKCMEMTMINPFKNLET-- 1044

  Fly  1109 HQLSISSTSPRSRQSSVEQELLFSSELDIQHNIQKTSEEIRHCFGGQYQTALAPNGFNGHLQYHD 1173
                                   ...|::::|:.|.:..                  ...:..||
Yeast  1045 -----------------------DKTLELKNNVGKRTSS------------------TDSVVIHD 1068

  Fly  1174 QGQQDSCASLSSNSKTQSSANTTQSN-----------TPESATMRL--------DNLERERTTQN 1219
            ...:|.  .||..:|..|.....|.|           ..:.:.:.|        :|.||:....|
Yeast  1069 DNDKDK--KLSEMTKIVSVYQLDQPNPAKEEDDIDMENSQKSDLNLSEIFQNSGENTERKLKDDN 1131

  Fly  1220 ---AKSPTDDAKVITVSINMAENGELILASNLMESEVVRV----------ALTLTKDQPVELLQT 1271
               .|..||..|:|.....:..||......:|.....:::          .:|:.:::.|.|.:.
Yeast  1132 EPTVKFSTDPPKIINEPEKLIGNGNENEKPDLETMSPIKINGDENMGQKQRITVKRERDVALTEQ 1196

  Fly  1272 SLTNLGICIKGGNCELPNKHFRSIMRML---------LNILEAEHTDVVIAGLHVL--------- 1318
            .       |.....:|.|......|.:|         |.:.|..|..:|.:..:.|
Yeast  1197 D-------INSKKMKLVNNKKSEKMHLLIMDNFPRDSLTVYEISHLLMVDSNGNTLMDFDVYFNH 1254

  Fly  1319 -SKIMRSNKMRHNWMHFLELILLKIIQCYQHSKEALRD-------IDSMIPRIAPSLPLDLSINI 1375
             ||.:...|.....|..:..::..:|.|:|:.|  :.|       .|.:         ||::|.:
Yeast  1255 MSKAINRIKSGSFTMKHINYLIEPLITCFQNQK--MTDWLTNENGFDEL---------LDVAIML 1308

  Fly  1376 VNPVIATGEFPTNLCAIKILLEVTEHHGSEITDAHLDIVFP----NLARSADDTQSMVR 1430
            :.....|...|:.:.:..|:|            .|..:|:.    .|:.:|||....||
Yeast  1309 LKSTDDTPSIPSKISSKSIIL------------VHCLLVWKKFLNTLSENADDDGVSVR 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	3/16 (19%)
		CLASP_N	<74..211	CDD:289144	25/141 (18%)
		HEAT repeat	90..120	CDD:293787	7/29 (24%)
		HEAT_2	129..>210	CDD:290374	12/80 (15%)
		HEAT repeat	131..154	CDD:293787	2/22 (9%)
		HEAT repeat	165..195	CDD:293787	4/29 (14%)
		CLASP_N	316..536	CDD:289144	51/233 (22%)
STU1	NP_009519.1	CLASP_N	318..560	CDD:403532	69/375 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21567
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100