DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and clasp2

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	NP_001315188.1	Gene:	clasp2 / 404604	ZFINID:	ZDB-GENE-040426-2343	Length:	1563	Species:	Danio rerio

Alignment Length:	1641	Identity:	508/1641 - (30%)
Similarity:	792/1641 - (48%)	Gaps:	256/1641 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSI-VCTDMGFL---IDGLMPWLTGSHFKIAQK 68
            ::|.|.||:.:.|:..::|:..:|:.:|||...|: |..|...|   ||.|..|:..|:||:|..
Zfish     6 NMDYFYQQVLQKDVTRRLQVGPELIDYLSDPQRSLDVEQDKPRLDKTIDELTGWVNSSNFKVALL 70

  Fly    69 SLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLA 133
            .::..|..:.||...|..|..||:|.::|||||::|.||::||.|:..||: :...|..:.::|.
Zfish    71 GIDIVSAFVDRLTDRFRGYIGTVVPALVDRLGDAKDQVRDQAQGLILKLMD-QTATPMYVWERLF 134

  Fly   134 TSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKH 198
            .. |||||.:.||.....:|:.|:.||.|.||:..::|.:|:|.||....||||||..|||:|:|
Zfish   135 PG-FKHKNFRSREGICFCVVSTLNAYGAQPLSLSKFVPHLCSLTGDQNPQVREAAITALVEVYRH 198

  Fly   199 VGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRERPT- 262
            ||:|:|.||.:. |:|:::|..:..:||:|...|.:..|..::.:     .|:.|::. ..||:
Zfish   199 VGERVRADLIKR-DLPSARLQTILSRFDEVLNSGNMALSLSQDRS-----FDDDDSVD-GSRPSS 256

  Fly   263 --------RMIKRPLHSAVSSSLRPKPNVNDVTG----DAGAVTMESFESSFEVVPQLNIFHAKD 315
                    ::.|:|..|| |||.||.......:|    .||||..|.|..:|..||.:.|:..:|
Zfish   257 AQAAFKVPKVPKKPAESA-SSSRRPSATGAAKSGASKEGAGAVDEEDFIKAFTDVPTVQIYSTRD 320

  Fly   316 MDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRS 380
            ::|...::..::||...||:.|.:||||||:||:........|.. .|:.|..:| .:..::|||
Zfish   321 LEDNLNKIREVLSDDKHDWDHRANALKKIRSLLVAGATDYDCFYQ-HLRLLDGAF-KLSAKDLRS 383

  Fly   381 QVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYTHAPKLLK 445
            ||:||||||:||:|..|.||.|.....|:..|.|||.|.|||:|::.|.|::.||::||.|:|:.
Zfish   384 QVVREACITVAYLSTLLGNKFDHGAEGIVPVLFNLIPNCAKVMATSGTAAIRIIIRHTHVPRLIP 448

  Fly   446 IYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSRYAYW 510
            :...... |||..:|....|.:.||.:||||.:|||:|.||.:::||.|.|||.:||..:|.|||
Zfish   449 LIASNCT-SKSVAVRRRCYEFLDLLLQEWQTHSLERHAAVLVESIKKGIRDADAEARVEARKAYW 512

  Fly   511 AFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGT-----GTGTGTAPETRRTVSRIGRTPGT 570
            ..|.|||..|:.:|.:|:.:.||.|:...:..|...:     .:.:.:.....|.:|:....||.
Zfish   513 GLRAHFPGEAESLYNSLESSYQRTLQSCLKSSGSVASLPQSDRSSSSSQESLNRPLSKWSAAPGR 577

  Fly   571 LQ-------KPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTGAAASGSLP 628
            :.       .|....||.|.||..||..||.|                :|.||...|...:|..|
Zfish   578 VPAGSKSSGSPASLQRSRSDVDVNAAAGAKAR----------------HSGQAGGAGRVTTGLTP 626

  Fly   629 ---------------------------------------RPRLNSNS------------------ 636
                                                   |.::.|.|
Zfish   627 GSYASLDDASDKDGRLRTKQTLSTASSVGSSQVDSRGRTRSKMASQSQRSDDSDCTPGSQSATPV 691

  Fly   637 -GGTPATTPG------------------SVTPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGN 682
             .|:.:.:||                  |..|....|:.:.:||..||.:|| |:|......|.:
Zfish   692 GAGSRSGSPGRVLASTALSTLSTGAQRVSAAPGSHRRSRIPRSQGCSRDSSP-TRLSVAPSNISH 755

  Fly   683 YYRGATGAIPKKASGIPR-----------STASSRETSPTRSGGGLMKRSMYSTGAGSRRTPE-- 734
            .|.|:.||   :.|.|||           |..|||:|||.||...|..|. ||...|:...|:
Zfish   756 IYNGSKGA---RGSRIPRPSVSQGCSREASRESSRDTSPVRSFTPLASRH-YSRSTGALHAPDAF 816

  Fly   735 --RNNPVRPSAAARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRK--------LMGRD 789
              ..:.:..|.::| |:.|..|...|..|.|  .:....|.:..|.||..:|        ..|..
Zfish   817 GAAGSGLGMSQSSR-LSSSVSAMRVLNTGSD--VEEALADALLLGDMRSKQKKPARRRYDTYGMY 878

  Fly   790 ESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSE 854
            ..||.:|:|||.|||||:.|       .|.|:         .|.....:|:..::..|||.:|||
Zfish   879 SDDDANSDASSACSERSYSS-------RNGSI---------PTYMRQTEDVAEVLNRCASANWSE 927

  Fly   855 RKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK--------------------VYSLF 899
            ||:||:.|...|.:.:.|::.:||.:.::|.:||.|.|:|                    |:|:|
Zfish   928 RKEGLMGLQALLKNHRTLSRVELKRLCEIFTRMFADPHSKRDPRGFGTVESGISSASFKRVFSMF 992

  Fly   900 LDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRI 964
            |:|:.:.|.||..:|.:|||:|||:|..|:|.|||.|:.:|:.|.|.|..|.||..||...|.|.
Zfish   993 LETLVDFIAVHKEDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFTILMRF 1057

  Fly   965 ISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELRSQAR 1029
            ..|.||||..|.::|||:::..| ....:..||.:  :......|.::.....:.||.::|..|:
Zfish  1058 TVDQTQTPNLKVKVAILKYIETL-TLQMEPQDFVN--TGETRLAVSRIITWTTEPKSSDVRKAAQ 1119

  Fly  1030 SCLVALYNLNTPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSS-----SPLSSSS 1089
            |.|::|:.||||:.|:||..|||.:||.|...:.:|:|....:..:...||.:     ||.|.||
Zfish  1120 SVLISLFQLNTPEFTMLLGALPKTFQDGATKLLQNHLRNTGNTAQASIGSPLTRHTPRSPASWSS 1184

  Fly  1090 PKPLQSPSVGPFASLQSHHHQLSISSTSPRSRQSSVE---QELLFSSELDIQHNIQKTSEEIRHC 1151
              ||.||:            ..|.::.||.:.....|   .|.::||...:...||..|  :|
Zfish  1185 --PLTSPT------------NTSQNTPSPSAFDYDTENMNSEEIYSSLRGVSQAIQNFS--VR-- 1231

  Fly  1152 FGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSN-TPESATMRL----DNL 1211
              .|......|....|     |.|::     :...::|..|..|...| |....||.|    ...
Zfish  1232 --SQEDMTEPPRKREG-----DGGEE-----VRKTNQTVDSGRTALDNKTSLLNTMPLLSSSPRP 1284

  Fly  1212 ERERTTQNAKSPTDDAKVITVSINMAENGE-LILASNLMESEVVRVAL--TLTKDQPVELLQTSL 1273
            .|:....|....:..:.....|:..|:..| |...|.:.:||||...|  .....:.||..:.:|
Zfish  1285 SRDYQPVNYSDSSFGSSSFNKSLKDADQEESLTDDSGVDQSEVVAELLKELSNHSERVEERKAAL 1349

  Fly  1274 TNLGICIKGGNCELPNKHFRSIMRMLLNIL-EAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLEL 1337
            ..|...|:.....:.::||::|:.:||..| :.||....:| |.||.:|:  |:....:.::.||
Zfish  1350 CELMRLIRETQLHVWDEHFKTILLLLLETLGDGEHVIRALA-LRVLKEIL--NRQPWRFKNYAEL 1411

  Fly  1338 ILLKIIQCYQH-SKEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEH 1401
            .::|.::.::. .||.:|..:.....:|.|:..|..|.::.|:|.:.::|.||.|||:|.:|.:.
Zfish  1412 TIMKALEAHKDPHKEVVRAAEEAASMLATSISPDQCIKVLCPIIQSADYPINLAAIKMLTKVIDR 1476

  Fly  1402 HGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNV 1466
            ...|.....|..:.|.|.:..|:::|.||||.|||:|.:|.|:||: :||.||.|:.||::|||:
Zfish  1477 LPKEGLIQMLPEIVPGLIQGYDNSESSVRKACVFCLVAIYAVIGED-LKPHLSQLSGSKLKLLNL 1540

  Fly  1467 YIEKQRNCISGGGSST 1482
            ||::.::..||...|:
Zfish  1541 YIKRAQSGSSGSDQSS 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	10/30 (33%)
		CLASP_N	<74..211	CDD:289144	59/136 (43%)
		HEAT repeat	90..120	CDD:293787	16/29 (55%)
		HEAT_2	129..>210	CDD:290374	37/80 (46%)
		HEAT repeat	131..154	CDD:293787	8/22 (36%)
		HEAT repeat	165..195	CDD:293787	14/29 (48%)
		CLASP_N	316..536	CDD:289144	92/219 (42%)
clasp2	NP_001315188.1	HEAT repeat	94..121	CDD:293787	13/26 (50%)
		HEAT repeat	133..158	CDD:293787	10/25 (40%)
		HEAT repeat	168..195	CDD:293787	13/26 (50%)
		HEAT	169..199	CDD:281045	15/29 (52%)
		CLASP_N	337..538	CDD:289144	89/203 (44%)
		HEAT repeat	1332..1354	CDD:293787	5/21 (24%)
		HEAT repeat	1367..1399	CDD:293787	13/34 (38%)
		HEAT repeat	1408..1441	CDD:293787	7/32 (22%)
		HEAT repeat	1446..1472	CDD:293787	10/25 (40%)
		HEAT repeat	1483..1512	CDD:293787	11/28 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594053
Domainoid	1	1.000	332	1.000	Domainoid score	I1119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	634	1.000	Inparanoid score	I808
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm25959
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	O	PTHR21567
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910