Protein Alignment chb and Togaram1

DIOPT Version :10

• Sequence 1: NP_524651.2
• Gene: chb / 43901
• FlyBaseID: FBgn0021760
• Length: 1491
• Species: Drosophila melanogaster
• Sequence 2: XP_234236.4
• Gene: Togaram1 / 314169
• RGDID: 1310474
• Length: 1826
• Species: Rattus norvegicus
• Alignment Length: 1685
• Identity: 316/1685 - (18%)
• Similarity: 576/1685 - (34%)
• Gaps: 507/1685 - (30%)

  Fly    11 GFIQQ------MPKADMRVKVQLAEDLVTFL------SDDTNSIVCTDMGFLIDGLMPWLTGSHF 63
            |.|.|      :.:.|.:.:.|..|:|...|      |...:|:|    || |..|...|..|:|
  Rat   348 GIIPQELHARLLDQEDYKNRTQAVEELKQLLGKFNPSSTPHSSLV----GF-ISLLYNLLDDSNF 407

  Fly    64 KIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQAL 128
            |:...:|:....|:.|||.....:...|:...:..|.|::..::::...:...||: .|.|.|.|
  Rat   408 KVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMK-EVGPQQVL 471

  Fly   129 IDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLV 193
              .|.....|||:::||||.:...:.:|..|.::...:......:...|.|....||:||::...
  Rat   472 --SLLLENLKHKHSRVREEVVNICICSLLTYPSEDFDLTKLSFDLAPALVDSKRRVRQAALEAFA 534

  Fly   194 EIYKHVGD-RLRPDLRRMDDVP----------ASKLAMLEQKFDQVKQEG-----LLLPSALKN- 241
            .:...:|. :.....:.:|.|.          |.:..:..:...::.::|     :|:||:.:.
  Rat   535 VLASSMGSGKTNVLFKAVDTVELQDNGDGVMNAVQARLARKTLPRLTEQGFVEYAILMPSSAQGR 599

  Fly   242 -------------TNGNGV-------GLDEADNIGL--RERPTRMIKRPLHSAVSSSLRP----K 280
                         .:||..       |....|::.|  ...||...:|.|.:....:..|    :
  Rat   600 SSHLAHGADTDWLMSGNRTQSAHCYCGDHTRDSMQLYGSYSPTICTRRVLSAGKGKNKLPWENEQ 664

  Fly   281 PNV---NDVTGDAGAVTMESFESSFEVVPQLNIFHAKDM---DDI---YKQVLVIISDKNADWEK 336
            |.|   |..:........|.| |:.:::|...:..::.|   ||:   .|:....:...:.|:..
  Rat   665 PGVMGENQTSNSKDIKDTEQF-SAHDLIPSPKLKPSQGMPVNDDLCFSKKRSSRNLFQSSRDFNS 728

  Fly   337 RVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRSQVIREACITIAYMSK-----T 396
              |::....|....:..|.   :..:..:|.||.:              .|.|.:..|.     |
  Rat   729 --DSIPTCGAGNTATLQTN---LPGKCGQLGLSQI--------------GCKTGSVGSDLQFLGT 774

  Fly   397 LRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKY-----------IIKY---------THAP 441
            .....|..|.|     :|....|.:...|.|.....|           :..|         .||.
  Rat   775 ANGHQDKVCAS-----LNFGSKSQQTFGSQSERTSSYSGSNASPGPFILPSYPLSSPRTSPKHAS 834

  Fly   442 KLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARRHSR 506
            .|      :::..||:|..::..       ..|..|:.|   .:.:.:.:|.:.:     ::.|.
  Rat   835 PL------SVSPKKSQDNSTSFS-------NSWPLKSFE---GLSKPSPQKKLAN-----QKSSN 878

  Fly   507 YAYWAFRRHFPELADQIYGTL--DIAAQRALEREREGGGGGGTGTGTGTAPETRR---------- 559
            .....|:.....:  |:..:|  ..:::|.|             .||...|...|
  Rat   879 PTGENFQEKTTPV--QLIPSLVRSPSSRRGL-------------NGTKPVPPIPRGISLLPDKAD 928

  Fly   560 --TVSRIGRTPGTLQKP------------------------TPSMRSISAVDTAAAQRAK----- 593
              ||..|.:.|..:.|.                        ..|:||:.  ::||.:|||
  Rat   929 LSTVGHIKKQPDDIWKSEKDNLTIDLSELNFRDKDLDQEEMQSSLRSLR--NSAAKKRAKLSGSS 991

  Fly   594 -----------VRAQYTLYSRQRKPLGPNNSNQASMTGAAASGSLPRPRLNSNSGGTPATTPGSV 647
                       ::.:.|:.|       |:.|:..:::..:.||...:..|.|           |:
  Rat   992 STSDVDSPDSAMKLELTIDS-------PSRSSSPNISSYSESGVYSQESLTS-----------SL 1038

  Fly   648 TPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGNYYRGATGAIPKKASGIPRSTASSRETSPTR 712
            :..|:|:..:|...|...|...||:|                :..||.|  |.:..||.....|.
  Rat  1039 STTPQGKRIMSDIFPTFGSKPCSTRL----------------SSAKKIS--PAAEQSSSAGITTS 1085

  Fly   713 SGGGLMKRSMYSTGAGSRRTPERNNPVRPSAAARLLAQSRE---AEHTLGVGDDGQPDYVSG-DY 773
            |...:.:|..|..|.|... .:|::.:.|||   |..|::|   .:||.|.........:|. |:
  Rat  1086 SVSIIGQRMNYGFGCGDFE-EDRSHDILPSA---LKIQNKEHPRHKHTKGFTRSSNLQQISSFDF 1146

  Fly   774 MRSGGMR------MGRKLMGRDESDDIDSEASSVCSERSFDSSYTRGNKSNYSL-------SGSH 825
            ..:..:.      :|:.:.|...|      |.:.|::....|.   .|:..:|:       ||.:
  Rat  1147 TATNTLSEDSVVIVGKGVFGNPNS------APTTCNQPVISSV---ENEDTFSVKPSIEPPSGIY 1202

  Fly   826 TRLDWSTQRAPF-----DDIETIIQFCASTH---WSERKDGLISLTQYLADGKELTQQQLK---- 878
            .|.  ..|..|.     :|.:|.:....||:   ..:||:     .:.|.|.|:..:::..
  Rat  1203 GRA--VQQNTPLYLDVENDKDTKVSIAKSTYDKMRQKRKE-----EKELFDAKDCERKETSPWER 1260

  Fly   879 -----------------CVLDMFR-KMFMDTHT---------KVYSLFLDTVTELILVHANELHE 916
                             .|:..:: :|...||:         :.:|.....:||.:.:.|:|  :
  Rat  1261 IKHPGTEKMTSENEPSPGVIPQYKERMSSVTHSPEIMDSLELRPFSKPEIALTEALRLLADE--D 1323

  Fly   917 W-------LFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTT 974
            |       .|:.....|:   :||||:.          :||         ..|.::.:.....:.
  Rat  1324 WEKKMEGLNFVRCLAAFH---SDLLNTK----------LHE---------TTFAVVQEVKNLRSG 1366

  Fly   975 KTRIAILRFLTDLANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLN 1039
            .:|.|:: .|.||. ||.|.|     ..|..:..|..|...|.:..:. :|......|.|:.|..
  Rat  1367 VSRAAVV-CLGDLF-TYLKKS-----MDQELDTAVRALLHKAGESNTF-IREDVDKALKAMVNNV 1423

  Fly  1040 TPQMTL--LLADLPKVYQDSARSCIHSHMR-----RQSQSCNSGANSPSSSPLSSSSPKPLQSPS 1097
            ||...:  |:.........:.|.|...|:.     .:.:..:|||...:...|          |:
  Rat  1424 TPARAVISLINGGQSHLHIAVRRCTAQHLADVVECMEPERISSGAKDMAERLL----------PA 1478

  Fly  1098 VGPFASLQSHHHQLSISSTSPRSRQSSVE-----QELLFSSELDIQH-NIQKTSEE--------- 1147
            ...||                  :.||.|     :::||   |.:.| |.:|..|:
  Rat  1479 AAKFA------------------QDSSQETRYYGRKMLF---LMMGHPNFEKLLEKYIPSKDLPY 1522

  Fly  1148 IRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNTPESATMRLDNLE 1212
            |:.......|..|      |.:..      |:.::....|.|.|..||..|:....|   ..:.|
  Rat  1523 IKESVKNLRQKGL------GEIPL------DTPSAKGRRSHTGSVGNTRSSSVSRDA---FSSSE 1572

  Fly  1213 RERT----------TQNAKSPTDDAKVITVSINM----------------AENGELILASNLME- 1250
            ||.|          .:|:....:..||||..:|.                .||.:.::..|:::
  Rat  1573 REVTEVREVPRKSAPRNSLESAEYIKVITGLLNAKDFRDRINGIKQLLSDTENNQELVVGNIVKI 1637

  Fly  1251 ------------SEVVRVALTLTKDQPVELLQTSLT---NLGI-CIKGGNCELPNKHFRSIMRML 1299
                        |:|..|||. |..:.:.||:.:|:   |:.| .|...|....|.   .|....
  Rat  1638 FDAFKSRLHDSNSKVNLVALE-TMHKMIPLLRDNLSPIINMLIPAIVDNNLNSKNP---GIYAAA 1698

  Fly  1300 LNILEA--EHTDVVIAGLHVLSKIMRSN-KMRHNWMHFLELILLKIIQCYQHSKE---------- 1351
            .|::.|  :|.|..:......:|....| |.:.:....|..|::::.|...|:.|
  Rat  1699 TNVVHALSQHVDNYLLLQPFCTKAQFLNGKAKQDMTEKLADIVMELYQRKPHATEQKVLVVLWHL 1763

  Fly  1352 ------------ALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVT 1399
                        |..:|.:...:::.:|...:..|::|.  |..:.|....:::.||:||
  Rat  1764 LGTMTHSGSLPGAGGNIRTATAKLSKALFTQMGQNLLNQ--AASQPPHIKKSLEELLDVT 1821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	8/27 (30%)
		HEAT	88..>195	CDD:441023	25/106 (24%)
		HEAT repeat	90..120	CDD:293787	5/29 (17%)
		HEAT repeat	131..154	CDD:293787	8/22 (36%)
		HEAT repeat	165..195	CDD:293787	6/29 (21%)
		CLASP_N	316..536	CDD:432496	39/252 (15%)
		PHA03307	568..>746	CDD:223039	43/217 (20%)
Togaram1	XP_234236.4	HEAT	98..237	CDD:441023
		HEAT repeat	395..419	CDD:293787	7/23 (30%)
		HEAT repeat	431..463	CDD:293787	4/31 (13%)
		HEAT repeat	470..497	CDD:293787	9/28 (32%)
		HEAT repeat	506..535	CDD:293787	6/28 (21%)
		HEAT repeat	545..570	CDD:293787	3/24 (13%)