DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and Togaram1

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	XP_234236.4	Gene:	Togaram1 / 314169	RGDID:	1310474	Length:	1826	Species:	Rattus norvegicus

Alignment Length:	1696	Identity:	292/1696 - (17%)
Similarity:	519/1696 - (30%)	Gaps:	605/1696 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GFIQQ------MPKADMRVKVQLAEDLVTFL------SDDTNSIVCTDMGFLIDGLMPWLTGSHF 63
            |.|.|      :.:.|.:.:.|..|:|...|      |...:|:|    || |..|...|..|:|
  Rat   348 GIIPQELHARLLDQEDYKNRTQAVEELKQLLGKFNPSSTPHSSLV----GF-ISLLYNLLDDSNF 407

  Fly    64 KIAQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQAL 128
            |:...:|:....|:.|||.....:...|:...:..|.|::..::::...:...||: .|.|.|.|
  Rat   408 KVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMK-EVGPQQVL 471

  Fly   129 IDKLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLV 193
              .|.....|||:::||||.:...:.:|..|.::...:......:...|.|....||:||::...
  Rat   472 --SLLLENLKHKHSRVREEVVNICICSLLTYPSEDFDLTKLSFDLAPALVDSKRRVRQAALEAFA 534

  Fly   194 EIYKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLR 258
            .:...:|              :.|..:|.:..|.|:.:          .||:||
  Rat   535 VLASSMG--------------SGKTNVLFKAVDTVELQ----------DNGDGV----------- 564

  Fly   259 ERPTRMIKRPLHSAVSSSLRPKPNVNDVTGDAGAVTMESFESSFEVVPQLNIFHAKDMDDIYKQV 323
                       .:||.:.|..|                       .:|:|
  Rat   565 -----------MNAVQARLARK-----------------------TLPRL--------------- 580

  Fly   324 LVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVDILKEELRSQVIREACI 388
                                          |:..||...:...|       ..:.||..:.....
  Rat   581 ------------------------------TEQGFVEYAILMPS-------SAQGRSSHLAHGAD 608

  Fly   389 TIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASAS-TIALKYIIKYTHAPKLLKIYTDT-- 450
            |...||.........:|.   :|    .::|.::..|.| ||..:.::........|....:.
  Rat   609 TDWLMSGNRTQSAHCYCG---DH----TRDSMQLYGSYSPTICTRRVLSAGKGKNKLPWENEQPG 666

  Fly   451 ---LNQ-SKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKS----IGDADCDARRHSRY 507
               .|| |.||||:.|         |::....|     :....||.|    :.|..|.:::.|..
  Rat   667 VMGENQTSNSKDIKDT---------EQFSAHDL-----IPSPKLKPSQGMPVNDDLCFSKKRSSR 717

  Fly   508 AYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPET--RRTVSRIGRTPGT 570
            ..:...|.|.  :|.|                ...|.|.|.|.....|..  :..:|:||...|:
  Rat   718 NLFQSSRDFN--SDSI----------------PTCGAGNTATLQTNLPGKCGQLGLSQIGCKTGS 764

  Fly   571 LQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTGAAASGS---LPRPRL 632
            :..      .:..:.||...:.||.|.....|:.::..|..:...:|.:|:.||..   ||...|
  Rat   765 VGS------DLQFLGTANGHQDKVCASLNFGSKSQQTFGSQSERTSSYSGSNASPGPFILPSYPL 823

  Fly   633 NSNSGGTPATTPGSVTPRPRGRAGVSQSQPGSRSTSPSTKLRDQYGGIGNYYRGATGAIPKK--- 694
            :|........:|.||:|:        :||..|.|.|.|..|:.        :.|.:...|:|
  Rat   824 SSPRTSPKHASPLSVSPK--------KSQDNSTSFSNSWPLKS--------FEGLSKPSPQKKLA 872

  Fly   695 --ASGIPRSTASSRETSPTRSGGGLMKRSMYSTGAGSRRTPERNNPVRPSAAARLLAQSREAEHT 757
              .|..|.......:|:|.:....|::      ...|||......||.|......|...:....|
  Rat   873 NQKSSNPTGENFQEKTTPVQLIPSLVR------SPSSRRGLNGTKPVPPIPRGISLLPDKADLST 931

  Fly   758 LG----VGDD---GQPDYVSGDY---------------------MRSGGMRMGRKLMGRDESDDI 794
            :|    ..||   .:.|.::.|.                     :|:...:...||.|...:.|:
  Rat   932 VGHIKKQPDDIWKSEKDNLTIDLSELNFRDKDLDQEEMQSSLRSLRNSAAKKRAKLSGSSSTSDV 996

  Fly   795 DSEASSVCSERSFD--SSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKD 857
            ||..|::..|.:.|  |..:..|.|:||.||.:::
  Rat   997 DSPDSAMKLELTIDSPSRSSSPNISSYSESGVYSQ------------------------------ 1031

  Fly   858 GLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTKVYSLFLDTVTELILVHANELHEWLFILL 922
              .|||..|:     |..|.|.::
  Rat  1032 --ESLTSSLS-----TTPQGKRIM----------------------------------------- 1048

  Fly   923 TRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKTRIAILRFLTDL 987
                    :|:..:..||            |...:|....:|...:.|:.:.....:.:..:...
  Rat  1049 --------SDIFPTFGSK------------PCSTRLSSAKKISPAAEQSSSAGITTSSVSIIGQR 1093

  Fly   988 ANTYCKSSDFPSDQSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLNTPQMTLLLADLPK 1052
            .|......||..|:|.....:.||                       :.|...|:
  Rat  1094 MNYGFGCGDFEEDRSHDILPSALK-----------------------IQNKEHPR---------- 1125

  Fly  1053 VYQDSARSCIHSHMRRQSQSCN---------SGAN----------------SPSSSPLSSSSP-- 1090
                      |.|.:..::|.|         :..|                :|:|:|.:.:.|
  Rat  1126 ----------HKHTKGFTRSSNLQQISSFDFTATNTLSEDSVVIVGKGVFGNPNSAPTTCNQPVI 1180

  Fly  1091 -----------KPLQSPSVGPFASLQSHHHQLSI-------------SSTSPRSRQSSVEQELLF 1131
                       ||...|..|.:......:..|.:             .||..:.||...|::.||
  Rat  1181 SSVENEDTFSVKPSIEPPSGIYGRAVQQNTPLYLDVENDKDTKVSIAKSTYDKMRQKRKEEKELF 1245

  Fly  1132 SSELDIQHNIQKTSEEIRHCFGGQYQTA-------LAPNGFNGHLQYHDQGQQDSCASLSSNSKT 1189
            .:: |.:.......|.|:|. |.:..|:       :.|       ||     ::..:|::.:.:.
  Rat  1246 DAK-DCERKETSPWERIKHP-GTEKMTSENEPSPGVIP-------QY-----KERMSSVTHSPEI 1296

  Fly  1190 QSSANTTQSNTPESATMR-----------------------------LDNLERERTT-------Q 1218
            ..|......:.||.|...                             |.|.:...||       :
  Rat  1297 MDSLELRPFSKPEIALTEALRLLADEDWEKKMEGLNFVRCLAAFHSDLLNTKLHETTFAVVQEVK 1361

  Fly  1219 NAKSPTDDAKVITVSINMAENGELI-LASNLMESEV---VRVAL-------TLTKDQPVELLQTS 1272
            |.:|....|.|:.:       |:|. .....|:.|:   ||..|       |..::...:.|:..
  Rat  1362 NLRSGVSRAAVVCL-------GDLFTYLKKSMDQELDTAVRALLHKAGESNTFIREDVDKALKAM 1419

  Fly  1273 LTNLG------ICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAG--------LHVLSKIMR 1323
            :.|:.      ..|.||...|.....|...:.|.:::|....:.:.:|        |...:|..:
  Rat  1420 VNNVTPARAVISLINGGQSHLHIAVRRCTAQHLADVVECMEPERISSGAKDMAERLLPAAAKFAQ 1484

  Fly  1324 SNKMRHNWMHFLELILL-------KIIQCYQHSKE------------------------------ 1351
            .:.....:.....|.|:       |:::.|..||:
  Rat  1485 DSSQETRYYGRKMLFLMMGHPNFEKLLEKYIPSKDLPYIKESVKNLRQKGLGEIPLDTPSAKGRR 1549

  Fly  1352 ---------------------ALRDIDSM--IPR-IAPSLPLDLS--INIVNPVIATGEFPTNLC 1390
                                 :.|::..:  :|| .||...|:.:  |.::..::...:|...:.
  Rat  1550 SHTGSVGNTRSSSVSRDAFSSSEREVTEVREVPRKSAPRNSLESAEYIKVITGLLNAKDFRDRIN 1614

  Fly  1391 AIKILLEVTEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSV 1455
            .||.||..||:: .|:...::..:|........|:.|.|...|:..:.|:..:| .:.:.|.:::
  Rat  1615 GIKQLLSDTENN-QELVVGNIVKIFDAFKSRLHDSNSKVNLVALETMHKMIPLL-RDNLSPIINM 1677

  Fly  1456 LNPSKV 1461
            |.|:.|
  Rat  1678 LIPAIV 1683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	8/27 (30%)
		CLASP_N	<74..211	CDD:289144	30/136 (22%)
		HEAT repeat	90..120	CDD:293787	5/29 (17%)
		HEAT_2	129..>210	CDD:290374	17/80 (21%)
		HEAT repeat	131..154	CDD:293787	8/22 (36%)
		HEAT repeat	165..195	CDD:293787	6/29 (21%)
		CLASP_N	316..536	CDD:289144	37/230 (16%)
Togaram1	XP_234236.4	HEAT repeat	181..203	CDD:293787
		HEAT repeat	214..241	CDD:293787
		HEAT repeat	251..285	CDD:293787
		HEAT repeat	395..419	CDD:293787	7/23 (30%)
		HEAT repeat	431..463	CDD:293787	4/31 (13%)
		HEAT repeat	470..497	CDD:293787	9/28 (32%)
		HEAT repeat	506..535	CDD:293787	6/28 (21%)
		HEAT repeat	545..570	CDD:293787	9/56 (16%)
		Spc7_N	<789..905	CDD:292045	30/137 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930