DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chb and Clasp1

DIOPT Version :9

Sequence 1:	NP_524651.2	Gene:	chb / 43901	FlyBaseID:	FBgn0021760	Length:	1491	Species:	Drosophila melanogaster
Sequence 2:	XP_038947154.1	Gene:	Clasp1 / 304740	RGDID:	1310970	Length:	1641	Species:	Rattus norvegicus

Alignment Length:	1758	Identity:	516/1758 - (29%)
Similarity:	805/1758 - (45%)	Gaps:	402/1758 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVC----TDMGFLIDGL-MPWLTGSHFKIAQK 68
            ::..:.|:.:.|:..::|:.::|:.:.||...|...    |.:..|:||| ..|:..|::|:...
  Rat     5 MESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLL 69

  Fly    69 SLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLA 133
            .::..|.|:.||...|.|...||||.:||||||::|:|||:.|.||..:|: :...||.:.|::.
  Rat    70 GMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMD-QAANPQYVWDRML 133

  Fly   134 TSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKH 198
            .. |||||.:.||.....::..|:..|.|.|::...:|.:|.|||||...||:|||.:|||||:|
  Rat   134 GG-FKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRH 197

  Fly   199 VGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNI-GLRERPT 262
            ||:|:|.||.: ..:|.|:|.::..|||:|::.|.::.||      |....|:.|:: |
  Rat   198 VGERVRADLSK-KGLPQSRLNVIFTKFDEVQKSGNMIQSA------NDKNFDDEDSVDG------ 249

  Fly   263 RMIKRPLHSAVSSSLRPKPNVNDVT--------------------GDAGAVTMESFESSFEVVPQ 307
               .||..::.|||..|..:..:|:                    ..||||..|.|..:|:.||.
  Rat   250 ---NRPSSASSSSSKAPSSSRRNVSMGTTRRLMASSLGSKSSAAKEGAGAVDEEDFIKAFDDVPV 311

  Fly   308 LNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVD 372
            :.|:.::|:::...::..|:||...|||:||:||||||:||:........|.. .|:.|..:| .
  Rat   312 VQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQ-HLRLLDGAF-K 374

  Fly   373 ILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKY 437
            :..::|||||:||||||:.::|..|.||.|....:|:..:.|||.||||::|::..:|::.||::
  Rat   375 LSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRH 439

  Fly   438 THAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDAR 502
            ||.|:|:.:.|.... |||..:|....|.:.||.:||||.:|||:.:||.:|:||.|.|||.:||
  Rat   440 THIPRLIPVITSNCT-SKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEAR 503

  Fly   503 RHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGG----------------------G 545
            ..:|..||.|..||...|:.:|.||:.:.|:||:...:....                      .
  Rat   504 IEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLKNSDSIVSLPQSDRSSSSSQESLNRPLS 568

  Fly   546 GTGTGTGTAPETRRTVS-RIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLG 609
            ...:.||:......||| :...|.|:||      ||.|.:|..||..||.:.
  Rat   569 AKRSPTGSTASRGSTVSTKSMSTTGSLQ------RSRSDIDVNAAASAKSKV------------- 614

  Fly   610 PNNSNQASMTGAAASGSLP--------------------------RPRLNSNSGGTPATTPGSVT 648
               |:.:..|..:::.:||                          |.|..| ||.|......|..
  Rat   615 ---SSSSGSTAFSSAAALPPGSYASLESRHMREDLEYVGLDAGRIRTRRQS-SGSTTNVASTSSD 675

  Fly   649 PRPRGRAG-VSQSQ---------PGSRSTSPSTKLRDQYGGIGNYYRGATGAIP-----KKASGI 698
            .|.|.||. |||||         .||||:||...|...|||:..   |::...|     :|.|.|
  Rat   676 SRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLAG---GSSRGPPVTPSSEKRSKI 737

  Fly   699 PRSTASSRETSPTRSG---GGLMKRSMYSTGAGSRRTPERNNPVRPSAAARLLAQSREAEHT--- 757
            |||...||||||.|.|   ...:.|...|.|.....:.|.:....|:.....||..|.:..|
  Rat   738 PRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFTPLASRRHSRSTSAL 802

  Fly   758 -----------LGVGDDGQ-PDYVS---------------GDYMRSGGMRMGRKLM-------GR 788
                       .|:|..|: |..||               .|.:..|..|..:|.:       |.
  Rat   803 STAESVGQSDRFGLGQSGRIPGSVSAMRVLSTSTDLEAAVADALLLGDARSKKKPVRRRYEPYGM 867

  Fly   789 DESDDIDSEASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWS 853
            ...||.:|:|||||||||:.|  ..|...:|              ....:|:..::..|||::||
  Rat   868 YSDDDANSDASSVCSERSYGS--RNGGIPHY--------------LRQTEDVAEVLNHCASSNWS 916

  Fly   854 ERKDGLISLTQYLADGKELTQQQLKCVLDMFRKMFMDTHTK------------------------ 894
            |||:||:.|...|...:.|::.:||.:.::|.:||.|.|:|
  Rat   917 ERKEGLLGLQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKIADSEAECEDKEGNLFPSEGSCPR 981

  Fly   895 VYSLFLDTVTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLK 959
            |:|:||:|:.:.|::|.::|.:|||:|||:|..|:|.|||.|:.:|:.|.|.|..:.||...|..
  Rat   982 VFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFN 1046

  Fly   960 ELFRIISDSTQTPTTKTRIAILRFLTDLANTYCKSSDFPSD--QSQACERTVLKLAQLAADQKSM 1022
            .|.|.|.|.||||..|.::|||:::..||    :..| |:|  .|......|.::.....:.||.
  Rat  1047 ILMRFIVDQTQTPNLKVKVAILKYIESLA----RQMD-PTDFVNSSETRLAVSRIITWTTEPKSS 1106

  Fly  1023 ELRSQAR---------------------------SC-------LVALYNLNTPQMTLLLADLPKV 1053
            ::|...|                           ||       |::|:.||||:.|:||..|||.
  Rat  1107 DVRKFQRQRSRAGDDVPGRSVPTCSGPGEANLEESCKQAAQIVLISLFELNTPEFTMLLGALPKT 1171

  Fly  1054 YQDSARSCIHSHMRRQSQSCNSGANSPS--------------SSPLSSSS--------------- 1089
            :||.|...:|:|::..|   |:|..|||              :|||:|.:
  Rat  1172 FQDGATKLLHNHLKNSS---NAGVGSPSNTIGRTPSRHPSSRTSPLTSPTNCSHGGLSPSRLWGW 1233

  Fly  1090 --------PKPLQSPSVGPFASLQSHHHQLSISSTSPRSRQSSVE---QELLFSSELDIQHNIQK 1143
                    |.|...|:..|.|.    .|:....|.||.......|   .|.::||...:...|:|
  Rat  1234 SADGLSKPPPPFSQPNSIPTAP----SHKTLRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEK 1294

  Fly  1144 TS--------EEIRHCFGGQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSNT 1200
            .|        |.|:.                       .|::| |..:|.:....|.|...:..:
  Rat  1295 FSFRSQEDLNEPIKR-----------------------DGKKD-CDIVSRDGGAASPATEGRGGS 1335

  Fly  1201 P-ESATMRLDNLERERTTQNAKS------------PTDDAKVITVSINMAENGEL---------- 1242
            . |...|.|||......||..::            |..|      :||..:...|
  Rat  1336 EVEGGRMALDNKTSLLNTQPPRAFPGPRAREYNPYPYSD------TINTYDKTALKEAVFDDDME 1394

  Fly  1243 -----------ILASNLMESEVVRVALTLTKDQPVELLQ-TSLTNLGICIKGGNCELPNKHFRSI 1295
                       ::|..|.|.......:...|...:|||: |...:||:.         .:||::|
  Rat  1395 QLRDVPIDHSDLVADLLKELSNHNERVEERKGALLELLKITREDSLGVW---------EEHFKTI 1450

  Fly  1296 MRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQCYQHS-KEALRDIDSM 1359
            :.:||..|..:...:....|.||.:|:|:...|  :.::.||.::|.::.::.| ||.:|..:..
  Rat  1451 LLLLLETLGDKDHSIRALALRVLREILRNQPAR--FKNYAELTIMKTLEAHKDSHKEVVRAAEEA 1513

  Fly  1360 IPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEHHGSE-ITDAHLDIVFPNLARSAD 1423
            ...:|.|:..:..|.::.|:|.|.::|.||.|||:..:|.|....| :....:||: |.|.:..|
  Rat  1514 ASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERITKESLLQLLVDII-PGLLQGYD 1577

  Fly  1424 DTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNVYIEKQRNCISGGGSSTKNSSAA 1488
            :|:|.||||:|||:|.:|.|:||: :||.|:.|..||::|||:||::         :.|.||:::
  Rat  1578 NTESSVRKASVFCLVAIYSVIGED-LKPHLAQLTGSKMKLLNLYIKR---------AQTTNSNSS 1632

  Fly  1489 SSS 1491
            |||
  Rat  1633 SSS 1635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	9/28 (32%)
		CLASP_N	<74..211	CDD:289144	62/136 (46%)
		HEAT repeat	90..120	CDD:293787	18/29 (62%)
		HEAT_2	129..>210	CDD:290374	36/80 (45%)
		HEAT repeat	131..154	CDD:293787	7/22 (32%)
		HEAT repeat	165..195	CDD:293787	14/29 (48%)
		CLASP_N	316..536	CDD:289144	90/219 (41%)
Clasp1	XP_038947154.1	CLASP_N	<77..208	CDD:403532	61/132 (46%)
		HEAT repeat	93..120	CDD:293787	15/26 (58%)
		HEAT repeat	132..157	CDD:293787	8/25 (32%)
		HEAT repeat	167..194	CDD:293787	14/26 (54%)
		HEAT	168..198	CDD:397231	17/29 (59%)
		CLASP_N	324..537	CDD:403532	90/215 (42%)
		RSRP	657..>925	CDD:293674	88/287 (31%)
		HEAT repeat	1384..1413	CDD:293787	3/28 (11%)
		HEAT repeat	1428..1478	CDD:293787	16/58 (28%)
		HEAT repeat	1488..1520	CDD:293787	8/31 (26%)
		HEAT repeat	1562..1591	CDD:293787	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1058
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41024
Inparanoid	1	1.050	599	1.000	Inparanoid score	I916
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm44807
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	LDO	PTHR21567
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980