Protein Alignment chb and CLASP1

DIOPT Version :9

• Sequence 1: NP_524651.2
• Gene: chb / 43901
• FlyBaseID: FBgn0021760
• Length: 1491
• Species: Drosophila melanogaster
• Sequence 2: XP_016859146.1
• Gene: CLASP1 / 23332
• HGNCID: 17088
• Length: 1588
• Species: Homo sapiens
• Alignment Length: 1708
• Identity: 513/1708 - (30%)
• Similarity: 814/1708 - (47%)
• Gaps: 355/1708 - (20%)

  Fly     9 LDGFIQQMPKADMRVKVQLAEDLVTFLSDDTNSIVC----TDMGFLIDGL-MPWLTGSHFKIAQK 68
            ::..:.|:.:.|:..::|:.::|:.:.||...|...    |.:..|:||| ..|:..|::|:...
Human     5 MESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVNSSNYKVVLL 69

  Fly    69 SLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALIDKLA 133
            .::..|.|:.||...|.|...||||.:||||||::|:|||:.|.||..:|: :...||.:.|::.
Human    70 GMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMD-QAANPQYVWDRML 133

  Fly   134 TSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEIYKH 198
            .. |||||.:.||.....::..|:..|.|.|::...:|.:|.|||||...||:|||.:|||||:|
Human   134 GG-FKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRH 197

  Fly   199 VGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRERPTR 263
            ||:|:|.||.: ..:|.|:|.::..|||:|::.|.::.||      |....|:.|::. ..||:
Human   198 VGERVRADLSK-KGLPQSRLNVIFTKFDEVQKSGNMIQSA------NDKNFDDEDSVD-GNRPS- 253

  Fly   264 MIKRPLHSAVSSSLRPKPNVNDVTG---------------------DAGAVTMESFESSFEVVPQ 307
                   ||.|:|.:..|:.....|                     .||||..|.|..:|:.||.
Human   254 -------SASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEEDFIKAFDDVPV 311

  Fly   308 LNIFHAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLILSYHTQPQFVAVQLKELSLSFVD 372
            :.|:.::|:::...::..|:||...|||:||:||||||:||:........|.. .|:.|..:| .
Human   312 VQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYDNFFQ-HLRLLDGAF-K 374

  Fly   373 ILKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKY 437
            :..::|||||:||||||:.::|..|.||.|....:|:..:.|||.||||::|::..:|::.||::
Human   375 LSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRH 439

  Fly   438 THAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDAR 502
            ||.|:|:.:.|.... |||..:|....|.:.||.:||||.:|||:.:||.:|:||.|.|||.:||
Human   440 THIPRLIPVITSNCT-SKSVAVRRRCFEFLDLLLQEWQTHSLERHISVLAETIKKGIHDADSEAR 503

  Fly   503 RHSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPETRRTVSRIGRT 567
            ..:|..||.|..||...|:.:|.||:.:.|:||:...:      ......:.|::.|:.|   .:
Human   504 IEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHLK------NSDSIVSLPQSDRSSS---SS 559

  Fly   568 PGTLQKPTPSMRSISAVDTAAAQRAKVRAQYTLYSRQRKPLGPNNSNQASMTGAAASGSLPRPRL 632
            ..:|.:|..:.||.:...|:.|.....::..|..|.||       |.......||||.   :.::
Human   560 QESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQR-------SRSDIDVNAAASA---KSKV 614

  Fly   633 NSNSGGTP-----ATTPGSV--------------------------------------------- 647
            :|:||.||     |..|||.
Human   615 SSSSGTTPFSSAAALPPGSYASLESRHMREDMEYIGLDSDGTTTKAEGRIRTRRQSSGSATNVAS 679

  Fly   648 TPRPRGRAG---VSQSQ---------PGSRSTSPSTKLRDQYGGI-GNYYRGATGAIP--KKASG 697
            ||..|||:.   |||||         .||||:||...|...|||: |...||.. ..|  :|.|.
Human   680 TPDNRGRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPP-VTPSSEKRSK 743

  Fly   698 IPRSTASSRETSPTRSG---GGLMKRSMYSTGAG---SRRTPERNNPVR---------------- 740
            ||||...||||||.|.|   ...:.|...|.|..   ||.:....:|.|
Human   744 IPRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFPPLDRFGLGQPGRI 808

  Fly   741 PSA--AARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRKLM-------GRDESDDIDS 796
            |.:  |.|:|:.|.:.|..:            .|.:..|..|..:|.:       |....||.:|
Human   809 PGSVNAMRVLSTSTDLEAAV------------ADALLLGDSRSKKKPVRRRYEPYGMYSDDDANS 861

  Fly   797 EASSVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDGLIS 861
            :|||||||||:.|  ..|...:|              ....:|:..::..|||::|||||:||:.
Human   862 DASSVCSERSYGS--RNGGIPHY--------------LRQTEDVAEVLNHCASSNWSERKEGLLG 910

  Fly   862 LTQYLADGKELTQQQLKCVLDMFRKMFMDTH------------------------TKVYSLFLDT 902
            |...|...:.|::.:||.:.::|.:||.|.|                        |:|:|:||:|
Human   911 LQNLLKSQRTLSRVELKRLCEIFTRMFADPHSKIADSEAECEDKEGNLFPSEVSCTRVFSMFLET 975

  Fly   903 VTELILVHANELHEWLFILLTRLFNKLGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISD 967
            :.:.|::|.::|.:|||:|||:|..|:|.|||.|:.:|:.|.|.|..:.||...|...|.|.|.|
Human   976 LVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRDSFPFDQQFNILMRFIVD 1040

  Fly   968 STQTPTTKTRIAILRFL---------TDLAN---------------TYCKSS------------- 995
            .||||..|.::|||:::         ||..|               |..|||
Human  1041 QTQTPNLKVKVAILKYIESLARQMDPTDFVNSSETRLAVSRIITWTTEPKSSDVRKSSLQRSRVG 1105

  Fly   996 -DFPSDQSQACERTVLKLAQLAADQKSME--LRSQARSCLVALYNLNTPQMTLLLADLPKVYQDS 1057
             |||:..:..|.         ...:.::|  .:..|:..|::|:.||||:.|:||..|||.:||.
Human  1106 EDFPTRSASTCS---------GPGEGNLEESCKQAAQIVLISLFELNTPEFTMLLGALPKTFQDG 1161

  Fly  1058 ARSCIHSHMRRQSQSCNSGANSPSS------SPLSSSSPKPLQSP---SVGPFASLQSHHHQLSI 1113
            |...:|:|::..|   |:...|||:      |..:||...||.||   |.|..:.....:...::
Human  1162 ATKLLHNHLKNSS---NTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSMLDYDTENL 1223

  Fly  1114 SS----TSPRSRQSSVEQELLFSSELDIQHNIQKTSEEIRHC-----FGGQYQTALAPNGFNGHL 1169
            :|    :|.|....::| :..|.|:.|:...|::..:  :.|     .||....|....|.:
Human  1224 NSEEIYSSLRGVTEAIE-KFSFRSQEDLNEPIKRDGK--KECDIVSRDGGAASPATEGRGGS--- 1282

  Fly  1170 QYHDQGQQDSCASLSSNSKTQ------------------SSANTTQSNTPESATMRLDNLERERT 1216
              ..:|.:.:..:.:|...||                  |.|..|...|.....:..|::|:.|.
Human  1283 --EVEGGRTALDNKTSLLNTQPPRAFPGPRARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRD 1345

  Fly  1217 TQNAKSPTDDAKVITVSINMAENGELILASNLMESEVVRVALTLTKDQPVELLQ-TSLTNLGICI 1280
            .     |.|.:.::...:.     ||   ||..|....|      |...:|||: |...:||:.
Human  1346 V-----PIDHSDLVADLLK-----EL---SNHNERVEER------KGALLELLKITREDSLGVW- 1390

  Fly  1281 KGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHFLELILLKIIQC 1345
                    .:||::|:.:||..|..:...:....|.||.:|:|:...|  :.::.||.::|.::.
Human  1391 --------EEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR--FKNYAELTIMKTLEA 1445

  Fly  1346 YQHS-KEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEVTEHHGSE-ITD 1408
            ::.| ||.:|..:.....:|.|:..:..|.::.|:|.|.::|.||.|||:..:|.|....| :..
Human  1446 HKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINLAAIKMQTKVVERIAKESLLQ 1510

  Fly  1409 AHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRLLNVYIEKQRN 1473
            ..:||: |.|.:..|:|:|.||||:|||:|.:|.|:||: :||.|:.|..||::|||:||::
Human  1511 LLVDII-PGLLQGYDNTESSVRKASVFCLVAIYSVIGED-LKPHLAQLTGSKMKLLNLYIKR--- 1570

  Fly  1474 CISGGGSSTKNSSAASSS 1491
                  :.|.||:::|||
Human  1571 ------AQTTNSNSSSSS 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chb	NP_524651.2	HEAT repeat	50..78	CDD:293787	9/28 (32%)
		CLASP_N	<74..211	CDD:289144	62/136 (46%)
		HEAT repeat	90..120	CDD:293787	18/29 (62%)
		HEAT_2	129..>210	CDD:290374	36/80 (45%)
		HEAT repeat	131..154	CDD:293787	7/22 (32%)
		HEAT repeat	165..195	CDD:293787	14/29 (48%)
		CLASP_N	316..536	CDD:289144	90/219 (41%)
CLASP1	XP_016859146.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I1147
eggNOG	1	0.900	-	-		E1_KOG2956
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41024
Inparanoid	1	1.050	641	1.000	Inparanoid score	I815
Isobase	1	0.950	-	0	Normalized mean entropy	S7030
OMA	1	1.010	-	-		QHG59940
OrthoDB	1	1.010	-	-		D62708at33208
OrthoFinder	1	1.000	-	-		FOG0001668
OrthoInspector	1	1.000	-	-		otm40670
orthoMCL	1	0.900	-	-		OOG6_102734
Panther	1	1.100	-	-	LDO	PTHR21567
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2455
SonicParanoid	1	1.000	-	-		X1839
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820