DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment chb and CLASP2

DIOPT Version :9

Sequence 1:NP_524651.2 Gene:chb / 43901 FlyBaseID:FBgn0021760 Length:1491 Species:Drosophila melanogaster
Sequence 2:XP_006713103.1 Gene:CLASP2 / 23122 HGNCID:17078 Length:1553 Species:Homo sapiens


Alignment Length:1651 Identity:496/1651 - (30%)
Similarity:800/1651 - (48%) Gaps:265/1651 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KPSDLDGFIQQMPKADMRVKVQLAEDLVTFL-SDDTNSIVCTDMGFL---IDGLMPWLTGSHFKI 65
            :|..::.|..|:.:.|:..::|:.::|:.:| :....|.:..|:|.|   :|.|..|:..|::::
Human     2 EPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRV 66

  Fly    66 AQKSLEAFSELIKRLGSDFNAYTATVLPHVIDRLGDSRDTVREKAQLLLRDLMEHRVLPPQALID 130
            :...||..|..:.||.:.|.:|.|.|:..:|||:||::|.||::||.|:..||: :|.||..:.:
Human    67 SLMGLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMD-QVAPPMYIWE 130

  Fly   131 KLATSCFKHKNAKVREEFLQTIVNALHEYGTQQLSVRVYIPPVCALLGDPTVNVREAAIQTLVEI 195
            :|| |.|||||.:.||.....::..|:.:|.|.|.:...||.:|.|.||....||:|||..:|||
Human   131 QLA-SGFKHKNFRSREGVCLCLIETLNIFGAQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEI 194

  Fly   196 YKHVGDRLRPDLRRMDDVPASKLAMLEQKFDQVKQEGLLLPSALKNTNGNGVGLDEADNIGLRER 260
            |:|||:::|.||.:. .:|.::|.|:..|||:|:..|.::.|..|:.:     .|:.:::. ..|
Human   195 YRHVGEKVRMDLYKR-GIPPARLEMIFAKFDEVQSSGGMILSVCKDKS-----FDDEESVD-GNR 252

  Fly   261 PT-----------RMIKRPLHSAVSSSLRPKPNVN---DVTGDAGAVTMESFESSFEVVPQLNIF 311
            |:           :....|.:||........|.|.   ...|.||||..:.|..:|..||.:.|:
Human   253 PSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEGGAGAVDEDDFIKAFTDVPSIQIY 317

  Fly   312 HAKDMDDIYKQVLVIISDKNADWEKRVDALKKIRALLI---LSYHTQPQFVAVQLKELSLSFVDI 373
            .::::::...::..|:||...||::|.:||||||:||:   ..|....|.:.:....|.||    
Human   318 SSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLS---- 378

  Fly   374 LKEELRSQVIREACITIAYMSKTLRNKLDAFCWSILEHLINLIQNSAKVIASASTIALKYIIKYT 438
             .::|||||:||||||:|::|..|.||.|....:|:..|.||:.|||||:|::...|:::||::|
Human   379 -AKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHT 442

  Fly   439 HAPKLLKIYTDTLNQSKSKDIRSTLCELMVLLFEEWQTKALERNATVLRDTLKKSIGDADCDARR 503
            |.|:|:.:.|.... |||..:|....|.:.||.:||||.:|||:|.||.:|:||.|.|||.:||.
Human   443 HVPRLIPLITSNCT-SKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARV 506

  Fly   504 HSRYAYWAFRRHFPELADQIYGTLDIAAQRALEREREGGGGGGTGTGTGTAPETRR--------- 559
            .:|..|...|.|||..|:.:|.:|:.:.|::|:...:..|      ...:.|::.|         
Human   507 EARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSG------SVASLPQSDRSSSSSQESL 565

  Fly   560 --------------TV--------SRIGRTPGTLQKPTPSMRSISAVDTAAAQRAKVR--AQYTL 600
                          ||        |:....||:||      ||.|.:|..||..||..  |..::
Human   566 NRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQ------RSRSDIDVNAAAGAKAHHAAGQSV 624

  Fly   601 YSRQRKPLGPNNSNQAS----------MTGAAASGSLPRPRLNSNSGGTPATTPGSVTPRPRGRA 655
            .|.:   ||....|..|          :.|.|:.....|.:|::     |....|:.....|||:
Human   625 RSGR---LGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSA-----PLAGMGNAKADSRGRS 681

  Fly   656 G---VSQSQPGSRSTSP-----STKLRDQYGGIGNYYRGATGAIPKKASGIPRSTASSRETSPTR 712
            .   ||||||||||.||     :|.|.....|:......:..|  :|.|.||||...|||.||:|
Human   682 RTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASA--QKRSKIPRSQGCSREASPSR 744

  Fly   713 ---SGGGLMKRSMYSTGA---GSRRTPERNNPVR---PSAA------------------------ 744
               :....:.|...|.|.   .||.:....:|||   |.|:                        
Human   745 LSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLASRHHSRSTGALYAPEVYGASGPGYG 809

  Fly   745 ---ARLLAQSREAEHTLGVGDDGQPDYVSGDYMRSGGMRMGRK-------LMGRDESDDIDSEAS 799
               :..|:.|..|...|..|.|  .:....|.:..|.:|..:|       ..|....||.:|:||
Human   810 ISQSSRLSSSVSAMRVLNTGSD--VEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDAS 872

  Fly   800 SVCSERSFDSSYTRGNKSNYSLSGSHTRLDWSTQRAPFDDIETIIQFCASTHWSERKDGLISLTQ 864
            |.|||||:.|       .|.|:         .|.....:|:..::..|||::|||||:||:.|..
Human   873 SACSERSYSS-------RNGSI---------PTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQN 921

  Fly   865 YLADGKELTQQQLKCVLDMFRKMFMDTHTK-VYSLFLDTVTELILVHANELHEWLFILLTRLFNK 928
            .|.:.:.|::.:||.:.::|.:||.|.|.| |:|:||:|:.:.|.||.::|.:|||:|||:|..|
Human   922 LLKNQRTLSRVELKRLCEIFTRMFADPHGKRVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKK 986

  Fly   929 LGTDLLNSMHSKIWKTLQVVHEYFPTQLQLKELFRIISDSTQTPTTKT----------------- 976
            :|.|||.|:.:|:.|.|.|..|.||..||...|.|...|.||||:.||                 
Human   987 MGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKTVKPALRDQLHSFWSSKV 1051

  Fly   977 RIAILRFLTDLANTYCKSSDFPSD--QSQACERTVLKLAQLAADQKSMELRSQARSCLVALYNLN 1039
            ::|||:::..||    |..| |.|  .|......|.::.....:.||.::|..|:|.|::|:.||
Human  1052 KVAILKYIETLA----KQMD-PGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELN 1111

  Fly  1040 TPQMTLLLADLPKVYQDSARSCIHSHMRRQSQSCNSGANSPSSSPLSSSSPK-------PLQSPS 1097
            ||:.|:||..|||.:||.|...:|:|:|    :..:|..|...|||:..:|:       ||.||:
Human  1112 TPEFTMLLGALPKTFQDGATKLLHNHLR----NTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPT 1172

  Fly  1098 VGPFASLQSHHHQLSISSTSPRSRQSSVE------QELLFSSELDIQHNIQKTSEE---IRHCFG 1153
            .....:|..........:.:.....||:.      |...|.|:.|:...:::.|::   ...|.|
Human  1173 NTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGG 1237

  Fly  1154 GQYQTALAPNGFNGHLQYHDQGQQDSCASLSSNSKTQSSANTTQSN----TPESATMRLDNLERE 1214
                ..::.....|......|...|:.|||..:..|.||..:...|    :...:......|:..
Human  1238 ----PGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEA 1298

  Fly  1215 RTTQNAKSPTDDAKVITVSINMAENGELI------LASNLMESEVVRVAL----TLTKDQPVELL 1269
            ....:|....||..:        ::.:|:      |:::....|..::||    .||:::...:.
Human  1299 MFDDDADQFPDDLSL--------DHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVW 1355

  Fly  1270 QTSLTNLGICIKGGNCELPNKHFRSIMRMLLNILEAEHTDVVIAGLHVLSKIMRSNKMRHNWMHF 1334
                               ::||::|:.:||..|..:...:....|.||.:|:|....|  :.::
Human  1356 -------------------DEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPAR--FKNY 1399

  Fly  1335 LELILLKIIQCYQH-SKEALRDIDSMIPRIAPSLPLDLSINIVNPVIATGEFPTNLCAIKILLEV 1398
            .||.::|.::.::. .||.:|..:.....:|.|:..:..|.::.|:|.|.::|.||.|||:..:|
Human  1400 AELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKV 1464

  Fly  1399 TEHHGSEITDAHLDIVFPNLARSADDTQSMVRKAAVFCIVKLYFVLGEEKVKPKLSVLNPSKVRL 1463
            .|....|..:..|..:.|.|.:..|:::|.||||.|||:|.::.|:|:| :||.||.|..||::|
Human  1465 IERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDE-LKPHLSQLTGSKMKL 1528

  Fly  1464 LNVYIEKQRNCISGGGSSTKNSSAAS 1489
            ||:|| |:....|||...|.:.|..|
Human  1529 LNLYI-KRAQTGSGGADPTTDVSGQS 1553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
chbNP_524651.2 HEAT repeat 50..78 CDD:293787 8/30 (27%)
CLASP_N <74..211 CDD:289144 58/136 (43%)
HEAT repeat 90..120 CDD:293787 14/29 (48%)
HEAT_2 129..>210 CDD:290374 35/80 (44%)
HEAT repeat 131..154 CDD:293787 10/22 (45%)
HEAT repeat 165..195 CDD:293787 12/29 (41%)
CLASP_N 316..536 CDD:289144 90/222 (41%)
CLASP2XP_006713103.1 HEAT repeat 131..157 CDD:293787 11/26 (42%)
HEAT repeat 167..201 CDD:293787 18/33 (55%)
HEAT 168..198 CDD:281045 15/29 (52%)
CLASP_N 328..539 CDD:289144 90/216 (42%)
DUF2217 687..>791 CDD:287267 37/105 (35%)
HEAT repeat 1323..1345 CDD:293787 4/21 (19%)
HEAT repeat 1358..1389 CDD:293787 9/30 (30%)
HEAT repeat 1399..1432 CDD:293787 7/32 (22%)
HEAT repeat 1477..1506 CDD:293787 13/28 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158168
Domainoid 1 1.000 331 1.000 Domainoid score I1147
eggNOG 1 0.900 - - E1_KOG2956
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 641 1.000 Inparanoid score I815
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59940
OrthoDB 1 1.010 - - D62708at33208
OrthoFinder 1 1.000 - - FOG0001668
OrthoInspector 1 1.000 - - otm40670
orthoMCL 1 0.900 - - OOG6_102734
Panther 1 1.100 - - O PTHR21567
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2455
SonicParanoid 1 1.000 - - X1839
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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